摘要
目的探讨精氨酸对脓毒症患者白细胞分化抗原14(CD14+)单核细胞人类白细胞抗原-DR(HLA—DR)表达及体液免疫的影响。方法将62例脓毒症患者随机分为治疗组(n=32)和对照组(n=30),两组患者在诊断为脓毒症的首日和治疗7d后次日晨抽取外周静脉血,检测外周血HLA—DR/CD14+单核细胞表达百分率和免疫球蛋白,并记录患者生命体征及临床检验指标和28d病死率。治疗组在常规治疗的基础上加用精氨酸15g/d,连用7d。结果精氨酸治疗后,治疗组患者的外周血HLA—DR/CD14+单核细胞表达百分率较治疗前及对照组治疗后均升高(P〈0.05);血清IgG高于对照组(P〈0.01),IgA和IgM未见明显升高(P〉0.05);两组患者间28d病死率差异无统计学意义(P〉0.05)。结论精氨酸能够提高脓毒症患者外周血HLA—DR/CD14+单核细胞表达百分率,使IgG升高。
Objective To study the effect of arginine on the expressive rate of human leukocyte antigen- DR (HLA- DR)/CDI4 ~ monocytes and the humoral immunity in the patients with sepsis. Methods Sixty - two patients with sepsis were randomly divided into the treatment group ( n = 32) and control group (n = 30). The expressive rate of human leukocyte antigen- DR (HLA- DR)/CD14+ monocytes and immunoglobulin were measured on the first day of being diagnosed with sepsis and 7 - day after treatment, and the vital signs and clinical laboratory indicators and 28 d mortality were recorded. 15 g arginine was added once a day for 7 days in the treatment group. Results The expressive rate of HLA - DR/CD14+ monocytes and IgG were higher in the treatment group than those in the control group after treatment (P 〈 0.05 and P 〈 0.01, respectively). IgA and IgM were not significantly increased by the treatment (P 〉 0.05 ), and 28 d mortality showed no significant difference between the two groups (P 〉 0.05). Conclusion Arginine could increase the expression rate of HLA - DtL/CD14 + monocytes and IgG in the patients with sepsis.
出处
《中国急救医学》
CAS
CSCD
北大核心
2014年第5期388-391,共4页
Chinese Journal of Critical Care Medicine
基金
安徽省高校省级自然科学研究项目(KJ2009B049Z)