预防重型颅脑损伤并发应激性溃疡的研究现状

The current research status of prophylaxis of severe craniocerebral injury complicated with stress ulcer

应激性溃疡（stress ulcer，SU）是重型颅脑损伤最常见也是最严重的并发症之一，其发病机制复杂，发病率高，预防其发生、发展对患者的预后有着重要的意义。本文针对近年应用SU预防措施（如抑酸药物、早期肠内营养等）的利弊及研究现状做一简要综述。从评估危重患者应用应激性溃疡预防治疗（SUP）指征及合理有效地选择抑酸药方面，为临床工作提供参考。

Stress ulcer （SU） is one of the most common and serious complications of severe craniocerebral trauma. It has complicated pathogenesis and high incidence. Prophylaxis of SU and control upper gastrointestinal bleeding of patients with severe craniocerebral injury have important significance. This paper summarized the pros and cons of SU preventive measures （ such as acid suppression drugs, early enteral nutrition, etc. ）made a brief overview on the research status in recent years. The present article aimed to provide some references for clinical work by introducing how to assess the critically ill patient with stress ulcer prophylaxis （SUP） indications and to choose reasonable and effective acid suppression drugs.