调节P13K／Akt信号转导通路对脑缺血-再灌注后微血管生成机制的研究进展

Recent advances in research of the angiogenesis generation basing on PDK/Akt signaling pathway after the cerebral ischemia - reperfusion

磷脂酰肌醇-3激酶（P13K）／丝氨酸一苏氨酸蛋白激酶（Akt）信号转导通路参与调节脑缺血-再灌注后半暗带区微血管的生成，为缺血性脑血管疾病的临床治疗提供了新的途径。本文从调控缺氧诱导因子（HIF）、细胞内皮生长因子（VEGF）等相关因子的表达，促血管内皮祖细胞（EPCs）归巢和血管内皮细胞（VEC）迁移等方面，就近年来有关P13K／Akt信号转导通路在脑缺血-再灌注微血管生成机制方面的研究进展做一综述。

PI3K/Akt signaling pathway involving in the microvascular generation in ischemic penumbra after the cerebral ischemia -reperfusion provides a new way for the clinical treatment of ischemic cerebrovascular disease. This paper summarizes the newest research about the role of PI3K/Akt signaling pathway in the blood capillary generation after the cerebral ischemia - reperfusion by regulating the expression of HIF, VEGF and related factors and subsequently promoting vascular EPCs homing and VEC migration, etc.