肺与大肠LPS信号通路相关性的实验研究

The Experiment al Study on LPS Signal Path Correlation of Lung and Large Intestine

目的:研究肺与大肠LPS信号通路变化的相关性。方法:将实验大鼠随机分为生理组、高氧组、低氧组、限食组和限水组,通过测定肺与大肠中TLR4、MD2和CD14的变化观察肺与大肠LPS信号通路的相关性。结果:高氧组和低氧组中肺部TLR4和MD2增高时,肠部也有所增高(P<0.05),限食组和限水组中肠部TLR4和MD2增高时,肺部亦有增高(P<0.05)。结论:可以认为肺与大肠在LPS信号通路TLR4和MD2中有相关的协同识别。

Objective：To study LPS signal path changes of lung and large intestine .Methods：Mice were randomly divided into physio-logical group , hyperoxia group , hypoxia group , diet restriction group , water restriction group .The LPS signal path ’ s correlation of lung and large intestine was observed detecting changes of variation of TLR 4, MD2 and CD14 in lung and large intestine .Results： When TLR4 and MD2 in the lungs of hyperoxia group and hypoxia group increased , they also increased in the large intestines .When TLR4 and MD2 in the large intestines of diet restriction group and water restriction group increased , they also increased in the lungs .Conclusion：Lung and large intestine can be thought to have related synergy identification in TLR 4 and MD2 of LPS signal path .