种植体周围炎患者龈沟液中IL-18和MMP-13表达研究

Expression of interleukin-18 and matrix metalloprotease-13 in peri-implantitis patients

目的探讨龈沟液中白介素-18(IL-18)和基质金属蛋白酶-13(MMP-13)表达与种植体周围炎的关系,评价其作为种植体周围炎诊断客观指标的意义。方法选择2011年5月至2013年5月在佳木斯大学口腔医学院口腔种植科行ITI种植体种植的患者30例作为研究对象(种植体40颗),根据种植体周围情况将其分为健康种植体组(28颗)和炎症种植体组(12颗);将对侧同名健康天然牙作为对照(健康天然牙组,40颗)。分别检测各组的牙周探诊深度(PD)、出血指数(SBI)、龈沟液(GCF)量及GCF中的IL-18、MMP-13含量并进行分析。结果炎症种植体组的PD、SBI值显著高于健康种植体组和健康天然牙组,差异有统计学意义(P<0.05)。炎症种植体组的GCF量以及GCF中IL-18和MMP-13含量均高于健康种植体组和健康天然牙组,差异有统计学意义(P<0.05)。健康种植体组与健康天然牙组比较,两组的PD、SBI、GCF量以及GCF中IL-18和MMP-13含量的差异均无统计学意义(P>0.05)。结论 IL-18和MMP-13与种植体周围炎有密切关系,可作为种植体周围炎早期诊断的有效检测指标。

Objective To study interleukin-18 （IL-18） and matrix metalloprotease-13 （MMP-13） in response to peri-implantitis implant, and evaluate IL-18 and MMP-13 as an objective index for peri-implantitis diagnostic signifi- cance. Methods Collect 30 cases from Department of Oral Implantology, Affiliated $tomatology Hospital of Jiamusi University, which were implanted with ITI amounted to 40. All the implants were divided into health implant group （28） and inflammation implant group （12） , a group of 40 healthy teeth were collected as controls. Levels of IL-18 and MMP-13 from gingival crevicular fluid, GCF volume, PD and SBI were measured and analyzed. Results PD and SBI of inflammation implant group were higher than those of healthy natural teeth group and healthy implant group （P 〈 0.05） ; GCF of inflammation implant group and IL-18 and MMP-13 of GCF were higher than the healthy implant group and healthy natural teeth group（P 〈 0.05） ;PD, SBI, GCF and IL-18, MMP-13 of GCF had no significant difference between healthy implant group and healthy natural teeth group（P 〉 0.05）. Conclusion IL-18 and MMP-13 have close relation- ship with peri-implantitis, which may be used as implant effective detection index in early diagnosis of peri-implantitis.