细胞直接重编程技术——疾病治疗的新策略

Cell direct reprogramming technology-new strategies for the treatment of disease

细胞直接重编程技术是近年来兴起的重要生物技术,其广泛的应用可为疾病的治疗、模型的构建、再生医学的研究提供了一个新的方向。细胞直接重编程技术不同于诱导性多能干细胞技术,它可将一种终末分化细胞直接转变为另一种终末分化细胞,跨越了分化细胞去分化以及再定向分化为特定功能细胞的过程,因而可避免多能干细胞本身可能带来的安全隐患。对体细胞直接重编程技术的研究现状作一综述。

Direct reprogramming technology sheds light on new direction for disease therapy, animal model, regenerative medicine. Different from the iPS technology, using direct reprogramming, one terminal differentiated cell can be transdifferentiated into another kind of terminal differentiated cell type, avoiding the de-differentiation and re-differentiation processes that may lead to the security consider. Based on the above mentioned, this paper was prepared to summarize the current status of direct reprogramming process.