摘要
目的:探讨血清胱抑素C(CysC)在2型糖尿病肾病早期诊断中的价值,为临床治疗提供依据。方法:收集符合标准的2型糖尿病患者200例,根据尿白蛋白排泄率(UAER)将患者分为三组,即正常蛋白尿组48例、微量蛋白尿组91例和临床蛋白尿组61例,检测血清中CysC水平。结果:正常蛋白尿组血清CysC水平及UAER最低,临床蛋白尿组最高,三者之间比较,差异有显著性(P<0.05)。微量蛋白尿组与临床蛋白尿组血清CysC浓度与UAER呈显著正相关(r分别为0.081,0.670,P<0.05)。血清CysC诊断糖尿病肾病的灵敏度87.5%(133/152),特异度为93.75(45/48)。结论:血清CysC与2型糖尿病患者的早期肾损伤程度密切相关,具有较高的灵敏度与特异度,为糖尿病肾病早期诊断提供重要信息。
Objective:To investigate the value of serum cystatin C (CysC) in the early diagnosis of ne-phropathy induced by type 2 diabetes mellitus and to provide foundations for clinical treatment .Method:200 eligible patients with type 2 diabetes mellitus were collected and divided into 3 groups according to urine al-bumin excretory rate ( UAER) , namely, 48 patients in normal albuminuria group , 91 cases in microalbumin-uria group and 61 cases in clinical proteinuria group;the serum CysC levels were determined .Result: The CysC level and UAER of the normal albuminuria group were the lowest , while those of the clinical proteinuria group were the highest , and the difference among three groups was statistically significant ( P&lt;0.05) .The se-rum Cys C concentrations of the microalbuminuria group and the clinical proteinuria group were significantly positively correlative with UAER ( r =0.081 and 0.670 respectively , P&lt;0.05) .The sensitivity of serum Cy-sC in diagnosis of diabetic nephropathy was 87.5%( 133/152 ) , and the specificity was 93.75 ( 45/48 ) . Conclusion:Serum CysC is closely related with early kidney injury degree in patients with type 2 diabetes mellitus , has high sensitivity and specificity , and can provide important information for early diagnosis of dia-betic nephropathy .
出处
《河北医学》
CAS
2014年第5期751-753,共3页
Hebei Medicine
关键词
血清胱抑素
C
尿白蛋白排泄率
糖尿病肾病
2型糖尿病
Serum cystatin C
Urine albumin excretory rate
Diabetic nephropathy
Type 2 dia-betes mellitus