摘要
以自制聚苯乙烯磺酸钠离子交换树脂为载体,制备了盐酸倍他洛尔树脂缓释混悬剂用于眼部给药。所得载药树脂呈球形,平均粒径为26.4μm。以人工泪液为介质,采用Franz扩散池法考察了其体外释药性能。结果显示,本品0.5 h释药26.4%,10 h累积释药97.8%。流变学研究表明,该混悬剂具有液态凝胶特性,适于眼部给药。
The betaxolol hydrochloride-loading resins were prepared with self-made sodium polystyrene sulfonate ion-exchange resins as carriers, then the sustained-release suspension for ophthalmic delivery containing the above drug-loading resins was developed. The drug-loading resins were in spherical shape with an average particle size of 26.4 μm. The test of in vitro drug release from the suspension was performed in Franz diffusion cell with simulated tear fluid as release medium. The results showed that the cumulative release of the drug from the prepared suspension at 0.5 and 10 h were 26.4 % and 97.8 %. The theological investigation of the suspension showed that the product presented a liquid gel property and was suitable for ophthalmic drug delivery.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2014年第5期434-438,共5页
Chinese Journal of Pharmaceuticals
基金
“重大新药创制”科技重大专项(2011ZX0950100103)
关键词
盐酸倍他洛尔
离子交换树脂
眼用混悬剂
缓释
液态凝胶
betaxolol hydrochloride
ion-exchange resin
ophthalmic suspension
sustained-release
liquid gel
