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波普瑞韦合成路线图解

Graphical Synthetic Routes of Boceprevir
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摘要 波普瑞韦(boceprevir,1),化学名为(1R,2S,5S)-N-(4-氨基-1-环丁基-3,4-二氧代丁烷-2-基)-3-[(2S)-2-(叔丁胺基甲酰胺基)-3,
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2014年第5期491-494,共4页 Chinese Journal of Pharmaceuticals
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参考文献17

  • 1徐芹,董金华.Boceprevir[J].中国药物化学杂志,2011,21(5):409-410. 被引量:3
  • 2陈本川,陈历胜.抗丙型肝炎病毒药——Boceprevir[J].医药导报,2012,31(1):127-131. 被引量:2
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二级参考文献4

  • 1屈莉红,陈良,王介非.HCV NS3蛋白酶及抑制剂的研究进展[J].肝脏,2007,12(3):203-205. 被引量:6
  • 2VENKATRAMAN S, BOGEN S L, ARASAPPAN A, et al. Discovery of ( 1R,5 S ) -N- [ 3 -amino-I - (cyclobutylmethyl) -2, 3-dioxopropyl ] -3- [ 2 ( S ) - [ [ [ ( 1,1 -dimethylethyl ) amino ] carbonyl ] amino ] -3,3-dimethyl-1 -oxobutyl ] -6,6-dimethyl-3- azabicyclo [ 3.1.0 ] hexan-2 ( S ) -carboxamide ( SCH503034 ), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection [ J ]. J Med Chem, 2006,49 ( 20 ) : 6074 - 6086.
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