职业性慢性轻度镉中毒患者尿镉及尿β_2-微球蛋白水平跟踪观察

Tracing observations on urinary cadmium and urinary β_2-micro-globulin levels in occupational chronic mild cadmium poisoning cases

目的观察职业性慢性轻度镉中毒患者尿镉及尿β2-微球蛋白(β2-MG)水平的变化规律。方法对8例职业性慢性轻度镉中毒患者2005、2007、2008、2010和2012年度的尿镉与尿β2-MG水平(该指标为进行常用对数转换后的对数值)进行跟踪观察和分析比较。结果 2005年首次诊断时,8例患者尿镉水平为(86.71±24.04)mg/kg肌酐,在脱离镉接触后,尿镉水平呈下降趋势;2012年尿镉水平为(30.97±11.28)mg/kg肌酐,低于2005年水平(P<0.05)。2005年首次诊断时尿β2-MG水平的对数值为(3.62±0.30)mg/kg肌酐,脱离镉接触后仍有缓慢升高趋势;2012年尿β2-MG水平的对数值为(4.02±0.41)mg/kg肌酐,高于2005年水平(P<0.05)。结论慢性镉中毒患者脱离镉接触后,尿镉水平可有一定程度下降,而肾小管功能损害仍无好转迹象。

Objective To observe the variations of urinary cadmium and urinary β2-micro-globulin （β2-MG） in occupa-tional chronic mild cadmium poisoning .Methods The levels of urinary cadmium and urinary β2-MG （ it was transformed to a common logarithm） of 8 cases of occupational chronic mild cadmium poisoning were tracing observed , analyzed and compared in 2005, 2007, 2008, 2010 and 2012.Results The level of urinary cadmium was （86.71 ＆#177;24.04） mg/kg Cr in 2005.After 2 years＆#39;removal from cadmium exposure , it decreased obviously .In 2012, it was （30.97 ＆#177;11.28） mg/kg Cr and lower significantly than that in 2005 （P＆lt;0.05）.The logarithm value of urinary β2-MG level was （3.62 ＆#177;0.30） mg/kg Cr in 2005, but it trended to increase after removal from cadmium exposure .And in 2012, it was （4.02 ＆#177;0.41） mg/kg Cr and higher significantly than that in 2005 （ P＆lt;0.05 ） .Conclusion The level of urinary cadmium in chronic cadmium poisoning cases might decrease after removal from cadmium exposure , but without a sign of improvement in renal tubular dysfunction .