摘要
目的探讨AFP异质体阳性(AFP-L3/AFP≥10%)肝癌的超声及超声造影特点,为AFP异质体阳性肝癌患者预后差提供超声影像学依据。方法随机选择AFP异质体阳性肝癌57例(阳性组)和AFP异质体阴性肝癌30例(阴性组),对比分析2组的超声及超声造影表现,并行统计学分析。结果阳性组病灶最大径≥5 cm 41例(71.9%),多发或弥漫阳性组34例(59.6%),边缘不清或不规则阳性组39例(68.4%),回声不均匀阳性组43例(75.4%),侵犯血管及肝内转移阳性组为31例(56.1%),均显著高于阴性组(P<0.05);病灶呈高回声30例(52.6%),高于阴性组10例(33.3%),而低回声12例(21.1%),低于阴性组12例(40.0%),但2组无统计学差异(P>0.05)。超声造影:阳性组23例表现为"快进快出"16例(69.6%),"快进慢出"7例(30.4%);而阴性组15例表现为"快进快出"5例(33.3%),"快进慢出"10例(66.7%),2组差异具有统计学意义(P<0.05)。结论AFP异质体阳性肝癌超声检查具有肿瘤体积大、浸润性生长、易侵犯血管和发生肝内转移,增强以"快进快出"为主的影像学特点,提示预后不良。
Objective To investigate the imaging features of ultrasound and contrast-enhanced ultrasound of hepatocellu- lar carcinoma(HCC) with a positive AFP-L3. Methods The AFP-L3 positive HCC (n = 57 ) (positive group) and the AFP-L3 negative HCC ( n = 30) ( negative group) were randomly selected, the imaging findings of ultrasound and contrast- enhanced ultrasound were comparatively analyzed in the two groups by statistics. Results In the positive group,41 cases (71.9%) ≥5 cm in the lesions maximum diameter,34 cases (59.6%) in the multiple or diffuse,39 cases(68.4% ) in the unclear or irregular edge ,43 cases (75.4%) in the uneven echo ,22 cases( 38.6% ) in the invade blood vessels and 11 cases(19.3% ) intrahepatic metastasis in the positive group, marked higher than that of the negative group( P 〈 O. 05 ). But 30 cases(52.6% ) and 12 cases(21.1% ) in the lesions' high and low echo, the two groups were no signifi- cant difference(P 〉0.05). "Quickly in and quickly out" in 16 cases(69.6% ) and "quickly in and slow out" in 7 cases (30.4%) were showed in contrast-enhanced ultrasound of 23 cases in the positive group, which were difference compared with the negative group (P 〈 0.05). Conclusion The AFP-L3 positive HCC has the poor prognosis features in ultra- sound and contrast-enhanced ultrasound.
出处
《中华全科医学》
2014年第6期891-893,共3页
Chinese Journal of General Practice
关键词
肝细胞肝癌
甲胎蛋白异质体
二维灰阶超声
超声造影
Hepatocellular carcinoma
Alpha-fetoprotein variant
Two-dimensional gray-scale ultrasound
Contrast-en-hanced ultrasound