中枢性胆碱能系统——调节睡眠与炎症反应的桥梁

Central cholinergic system -- the bridge between controlling sleep and inflammatory response

背景对睡眠机制的研究有利于睡眠障碍疾病的治疗，也利于对麻醉机制的研究发展。多年研究表明，中枢性胆碱能系统在睡眠产生和维持中发挥重要作用。不仅如此，中枢性胆碱能系统还参与机体炎症反应调节。麻醉可以诱发中枢炎症反应，而炎症反应也影响意识状态和睡眠。目的评价中枢胆碱能系统对于睡眠和炎症反应调节的作用。内容详细描述中枢胆碱能系统对于睡眠和炎症反应的调节作用。趋向中枢性胆碱能系统是睡眠或麻醉和炎症反应调节的桥梁。以中枢性胆碱能系统为靶点，通过对其调节可以在精细调控麻醉状态的同时减轻麻醉的副作用，如对认知功能的不良影响。

Background Studies of the mechanisms of sleep not only benefits the treatment of sleep disorder related diseases, but also benefits reseachs relating to mechanisms of anesthesia. Studies over the years show that the central cholinergic system plays a great role in the production and maintenance of sleep. At the same time it also takes part in regulating the systemic inflammatory response. General anesthesia is able to cause central nervous systemic inflammatory response, this inflammatory response in turn affects the state of consciousness and sleep. Objective Aim of this review is to evaluate effects of central cholinergic system on sleep and inflammatory response. Content The regulation effects of central cholinergic system on sleep and inflammatory response have been introduced in details. Trend The central cholinergic system is a bridge between sleep/general anesthsian and inflammatory response, therefore controlling it can help to precisely regulate general anesthesia as well as reduce general anesthesia associated side effects, such as negative effects on recognition.