两性霉素B对感染口腔假丝酵母菌的失效性分析

Amphotericin B to Infection of Oral Candida Failure Analysis

目的：分析两性霉素B对医院口腔感染假丝酵母菌的失效性。方法：给予830例口腔感染患者两性霉素B治疗，初始3d的剂量是1、3、5 mg，加入5%葡萄糖溶液40 mg，保持速度是4 mL/h，从第4天开始每日增加4 mg，直至20 mg，后续保持该剂量；持续1～3个月的疗程，总用药量是1～1.5 g，并采用假丝酵母菌R因子检测方法分析两性霉素B对感染口腔假丝酵母菌的失效性。结果：从60株多重抗药性假丝酵母菌中分离出39株R因子，阳性率为65.5%，40株假丝酵母菌R因子的抗药性基因结构中3种以上抗药性基因者占有90%；结论：假丝酵母菌对两性霉素B的抗药性与传递R因子具有较强的关联性，利用R因子对两性霉素B对感染口腔假丝酵母菌失效性的分析具有安全和高效性的特征。

Objective：to analyze amphotericin B for hospital oral cavity infection of candida of failure. Method：830 cases of oral infection patients＇ amphotericin B therapy, the dose of initial 3 d is 1, 3, 5 mg and 40 mg in 5%glucose solution, maintain speed is 4 ml/h, starting from the fourth day on 4 mg per day, until 20 g, subsequent keep the dose; Last 1 to 3 months of treatment, the total dose is 1-1.5 g, and USES the candida R factor analysis of amphotericin B test method for the failure of oral candida infection. Results：from 60 strains of multidrug-resistant 39 strains of candida isolated R fac-tor, positive rate was 65.5%, 40 strains of candida R factor resistance gene structure of the above three kinds of resistant genes accounts for 90%; Candida. Conclusion：the resistance of amphotericin B with the transfer of R factor has strong correlation, by using R factor of amphotericin analysis of the failure of oral candida infection sex has the characteristics of safety and efficiency.