急性心肌梗死患者NT-proBNP与HCY检测临床意义

Detection of N-terminal Pro-brain Natricuretic Peptide and Homocysteine Levels in Patients with Acute Myocardial Infarction

目的探讨急性心肌梗死(AMI)患者血清生物标志物氨基末端B型钠尿肽原(NT-proBNP)与同型半胱氨酸(HCY)检测临床意义。方法收集本院AMI患者53例及同期健康对照组50名,分别采集静脉血2mL,检测血清NT-proBNP和HCY水平。根据ROC曲线判断两者水平对急性心肌梗死患者的诊断价值。结果 AMI组治疗前NT-proBNP(2032.01±423.50)pg/mL,HCY(18.11±5.62)μmol/L,明显高于治疗后的(405.14±344.01)pg/mL、(14.68±2.84)μmol/L,也高于健康对照组的(62.69±28.91)pg/mL、(13.72±3.44)μmol/L,差异具有统计学意义(P<0.05)。血清NT-proBNP和HCY对AMI最佳分界诊断界值分别为51.42pg/mL和13.13μmol/L。结论血清NT-proBNP和HCY的检测对早期AMI具有较好的诊断灵敏性和特异性,能为AMI患者提供早期风险预测以及指导临床科学治疗。

Objective To evaluate the diagnostic value of serum N-terminal pro-brain natricuretic peptide（NT-proB-NP）and homocysteine（HCY）levels in acute myocardial infarction（AMI）patients. Methods Fifty-three AMI pa-tients were selected and 50 healthy people served as control group. Two mL fasting vein blood was collected fromboth patients and controls and the serum levels of NT-proBNP and HCY were measured before and after treatmentin AMI patients. The diagnostic value of the two biomarkers for AMI was analyzed according to ROC curve. Re-sults The NT-proBNP [（2032.01±423.50）pg/mL] and HCY [（18.115.62）μmol∕L] in AMI group before treatmentwere both higher than those after treatment[NT-proBNP（405.14±344.01）pg∕mL and HCY（14.68±2.84）μmol∕L], and were also higher than those in control group [NT-proBNP（62.69±28.91）pg∕mL and HCY（13.72±3.44）μmol/L], allwith significant differences（P〈0.05）. The better cut-off values of NT-proBNP and HCY were 51.42pg/mL and13.13μmol∕L, respectively. Conclusion Serum NT-proBNP and HCY have good sensitivity and specificity to earlydiagnosis of AMI, so they might be used as predictors of early AMI and guide for treatment.