冠心病患者冠脉循环中血浆线粒体偶联因子-6含量与冠脉狭窄程度的相关性(英文)

Correlation between plasma mitochondrial coupling factor-6 level in coronary circulation and coronary stenotic degree in CHD patients

目的：研究冠心病（CHD）患者冠脉循环中血浆线粒体偶联因子－6（MCF－6）含量与冠脉狭窄程度的相关性。方法：选择冠心病患者64例（冠心病组），根据冠脉病变程度分为单支、双支、多支病变组；另选冠脉正常者20例作为正常对照组，用放免方法分别测定各组外周、冠状窦、冠状窦与主动脉根部血浆MCF－6浓度，并用多元线性逐步回归分析分析冠脉循环血浆MCF－6含量与冠脉狭窄程度的相关性。结果：冠心病患者外周、主动脉根部、冠状窦血浆MCF－6浓度较正常对照组均显著升高（P〈0．05）；冠心病组冠状窦血浆MCF－6浓度较主动脉根部及外周血的均显著升高[（402±56）pg／ml比（348±48）pg／ml比（340±51）pg／ml，P〈0．01]；多支病变组的血浆MCF－6浓度较单支、双支病变组的显著升高（P〈0．05～0．01）；多元线性逐步回归分析显示冠状窦及主动脉根部血浆MCF－6浓度与Gensini积分均呈明显正相关（r=0．650，P〈0．01；r＝0．711，P〈0．01）。结论：线粒体偶联因子－6参与了冠心病的病理生理过程，在冠心病的发病过程中可能是一种较为重要的血管活性物质。

Objective： To study correlation between plasma mitochondrial coupling factor-6 （MCF-6） level in coronary circulation and coronary stenotic degree in CHD patients. Methods： A total of 64 CHD patients were selected as CHD group, and they were further divided into single-vessel group, double-vessel group and multi-vessel coronary disease group; another 20 cases with normal coronary artery were enrolled as normal control group. Radioimmunoassay method was used to measure plasma MCF-6 concentration in peripheral, coronary sinus and aortic root in each group. Multivariant linear gradual regressive analysis was used to analyze above-mentioned correlation. Results： Compared with normal control group, there was significant increase in plasma MCF-6 concentration in peripheral, aortic root and coronary sinus in CHD patients （P〈0.05 all） ; compared with aortic root and peripheral plasma, there was significant increase in MCF-6 concentration [（348±48） pg/ml vs. （340±51） pg/ml vs. （402±56） pg/ml, P〈0.01 all] in coronary sinus of CHD group; Compared with single-vessel group, double-vessel group, there were increase in MCF-6 concentration in multi-vessel coronary disease group （P 〈 0.05 -〈0.01） ; Multivariant linear gradual regressive analysis indicated that Gensini score was significant positively correlated with plasma MCF-6 concentrations in coronary sinus and aortic root （ r = 0. 650, P〈0.01 ; r = 0.711, P〈0.01）. Conclusion： Mitochondrial coupling factor-6 participates in the pathophysiological process of coronary heart disease, which may be an important vasoactive substance during development of coronary heart disease.