库欣综合征对代谢指标的影响

Influence of Cushing′s syndrome on metabolic indexes

目的:比较库欣综合征与原发性高血压对代谢指标的影响。方法:选择22例经病理证实为库欣综合征的患者(库欣组)和22例同期住院并且年龄、性别、民族、人体质重指数、平均血压水平与之匹配的原发性高血压患者(高血压组),比较两组的空腹血糖(FBG)、餐后2h血糖(2hPBG)、空腹胰岛素(FINS)、餐后2h胰岛素(2hINS)、稳态模型胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)等指标,并进行统计学分析。结果:与高血压组比较,库欣组FBG[(4.75±0.44)mmol/L比(6.31±0.51)mmol/L]、FINS[(13.04±2.68)mU/L比(29.05±2.92)mU/L]、2hPBG[(7.32±0.82)mmol/L比(8.96±1.14)mmol/L]、2hINS[(37.66±9.21)mU/L比(104.45±23.14)mU/L]、HOMA-IR[(2.57±0.44)比(7.96±0.56)]、TC[(4.15±0.93)mmol/L比(5.17±1.35)mmol/L]、TG[(1.44±0.87)mmol/L比(2.24±1.25)mmol/L]水平均显著升高(P<0.05或<0.01)。结论:库欣综合征与原发性高血压相比,有更多的代谢改变和更明显的胰岛素抵抗。

Objective：To compare influence of Cushing＆#39;s syndrome and essential hypertension （EH）on metabolic in-dexes.Methods：A total of 22 pathologically confirmed patients With Cushing＆#39;s syndrome Were regarded as Cushing group and 22 EH patients,Who admitted in the same period With matched age,gender,nationality,body mass index （BMI）and mean blood pressure level for Cushing group,Were enrolled as EH group.Fasting blood glucose （FBG）,＆amp;nbsp;2h postprandial blood glucose （2hPBG）,fasting insulin （FINS）,2h postprandial insulin （2hINS）,homeostasis mod-el-insulin resistance index （HOMA-IR）,total cholesterol （TC）,triglyceride （TG）and high density lipoprotein cho-lesterol （HDL-C）etc.Were compared betWeen tWo groups,and they Were statistically analyzed.Results：Com-pared With EH group,there Were significant increase in FBG [（4.75±0.44）mmol/L vs.（6.31±0.51）mmol/L], FINS [（13.04±2.68）mU/L vs.（29.05±2.92）mU/L],2hPBG [（7.32±0.82）mmol/L vs.（8.96±1.14）mmol/L],2hINS [（37.66±9.21）mU/L vs.（104.45±23.14）mU/L],HOMA-IR [（2.57±0.44）vs.（7.96±0.56）], TC [（4.15±0.93）mmol/L vs.（5.17±1.35）mmol/L]and TG [（1.44±0.87）mmol/L vs.（2.24±1.25）mmol/L]in Cushing group,P〈0.05 or〈0.01.Conclusion：Compared With essential hypertension,there are more meta-bolic changes and more obvious insulin resistance in Cushing＇s syndrome.