静磁场对糖尿病大鼠表皮创伤的抑制作用

Inhibitive Effects of Static Magnetic Field on Wound Healing in Diabetes Rat

目的:系统评估180 mT静磁场对由链脲佐菌素诱发糖尿病的大鼠的创伤治疗效果,以期为其临床应用提供有力的实验依据。方法:取48只3月龄雄性Sprage-Dawley大鼠,随机平均分为对照组、糖尿病创伤组和静磁场治疗组。于大鼠背部表皮行1.5 cm的圆形创口,创口由水胶体敷料覆盖,磁场组的胶体上黏附有静磁片。于实验第5、12和19天,每组随机处死4只大鼠进行创伤面积测量。结果:静磁场作用明显提高了糖尿病大鼠在第5、12和19天的表皮创伤的愈合率(P<0.05),缩短了愈合时间(P<0.05)。结论:作为一种廉价、安全且无创的治疗方法,180 mT静磁场在促进糖尿病患者伤口愈合方面具有良好的临床应用前景。

Objective To evaluate the therapeutic effects of 180 mT moderate intensity gradient static magnetic field （SMF） on diabetes-induced epidermal wounds healing in rats, and to provide adequate basis for its clinical application to diabetic wound healing. Methods Totally 48 3-month male Sprague-Dawley rats were divided into a control group, a diabetes-induced wound group and a SMF therapy group. An 1.5-era round wound was made on the back of each rat, which was covered with hydrocolloid dressing. Some static magnetic sheets adhered to the hydrocolloid dressings for SMF group. Four rats in each group were executed respectively at the 5th, 12th, and 19th day, and measured for the wound size. Results SMF significantly enhanced the wound healing rate of epidermal wounds in diabetes rats at day 5, 12 and 19, with P〈0.05, and decreased the time statistically, with P〈0.05. Conclusion SMF of 180 mT is low-cost, safe and noninvasive, and thus is worth applying clinically for wound healing in diabetes rats.