摘要
目的:探讨血清N末端B型钠尿肽原(NT-proBNP)和心脏型脂肪酸结合蛋白(h-FABP)在胸部创伤所致心肌挫伤的早期监测价值,并观察重组人生长激素(rhGH)的治疗效果。方法:选择82例胸部创伤合并心肌挫伤患者(挫伤组)和50例健康人(对照组)为研究对象,挫伤组采用rhGH治疗。血清NT-proBNP检测采用电化学发光免疫分析(ECLIA)法,血清h-FABP检测采用双抗体夹心酶联免疫(ELISA)一步法。结果:治疗前血清h-FABP阳性率(41.4%)显著高于NT-proBNP(29.8%)及心电图(ECG)(17.7%)(P<0.01)。治疗前,胸部创伤合并心肌挫伤患者血清NT-proBNP和h-FABP水平分别与对照组比较差异有统计学意义(P<0.01);治疗后,两者水平均显著低于治疗前(P<0.01),与对照组比较,差异无统计学意义(P>0.05)。胸部创伤合并心肌挫伤患者血清NT-proBNP与h-FABP呈显著正相关(r=0.719,P<0.01),相关性良好。胸部创伤合并心肌挫伤的82例患者经rhGH治疗后,血清NT-proBNP和h-FABP水平达正常,ECG也无异常表现,无一例死亡病例。结论:rhGH对胸部创伤合并心肌挫伤具有临床治疗作用,血清NT-proBNP和h-FABP的联合检测可早期诊断胸部创伤合并心功能及心肌细胞损害,也可观察临床疗效。
Objective:Through the observation of chest trauma caused by myocardial contusion patients serum N - termi- nal pro - B - type natriuretic peptide ( NT - proBNP) and heart - type fatty acid binding protein ( h - FABP) level change, discuss the merger to early cardiac function and myocardial cell damage monitoring value, to observe the clinical efficacy of re- combinant human growth hormone (rhGH) treatment. Methods : A total of 82 patients with chest trauma combined with myocar- dial contusion (contusion group) and cases of control group as the research object, contusion group using rhGH treatment. Ser- um NT - proBNP detection using electrochemiluminescence immunoassay ( ECLIA ) method, serum h - FABP detection using enzyme- linked immunosorbent assay (ELISA) method. Results:Before treatment serum h - FABP positive rate (41.4%) was statistically higher than NT - proBNP (29.8%) and ECG ( 17.7% ) ( P 〈 0.01 ). Before treatment NT - proBNP and h - FABP were significantly higher than those in the control group(P 〈 0.01 ). After treatment level significantly (P 〈 0.01 ), and the control group there was no significant difference in sex( P 〉 0. 05 ). Serum NT- proBNP and h -FABP is a significant posi- tive correlation( r =0. 719, P 〈 0.01 ), and the correlation is good. 82 patients after treatment by rhGH, serum NT -proBNP and h - FABP level of normal, ECG and no abnormality, no 1 deaths. Conclusion: rhGH chest trauma to merge myocardial con- tusion therapeutic effect, combined detection of serum NT - proBNP and h - FABP level and can be early diagnosis chest trau- ma combined cardiac function and myocardial cell damage, and clinical curative effect observation.
出处
《临床医药实践》
2014年第5期334-337,共4页
Proceeding of Clinical Medicine
关键词
胸部创伤
N末端B型钠尿肽原
心脏型脂肪酸结合蛋白
重组人生长激素
早期诊断
临床疗效
chest trauma
N - terminal pro - B - type natriuretic peptide
heart - type fatty acid binding protein
recom- binant human growth hormone
early diagnosis
clinical curative effect