摘要
阻塞性睡眠呼吸暂停综合征(Obstructive Sleep Apnea Syndrome,OSAS)是一种与肥胖密切相关的全球性疾病,大量的研究表明OSAS是心脑卒中独立的危险因素,其核心的致病机制是间断性缺氧(Intermittent Hypoxia,IH)。本文阐述IH可能导致动脉粥样硬化(atherosclerosis,AS)的炎症通路,探讨通路之间的相互联系,为后续研究IH的分子机制奠定基础,同时为临床治疗OSAS提供理论依据。
Obstructive Sleep Apnea Syndrome（ OSAS） is a global disease,which is closely related to obesity. A large number of studies have shown that OSAS is an independent risk factor for cardio-cerebral apoplexy,and the pathogenic mechanism is intermittent hypoxia（ IH）. This paper explained the possible inflammatory pathways that IH resulted in atherosclerosis（ AS）,and discussed the interaction among various pathways, which would lay the foundation for the follow-up studies on the molecular mechanism of IH,and provide theoretical basis for clinical treatment of OSAS.
出处
《包头医学院学报》
CAS
2014年第2期133-135,共3页
Journal of Baotou Medical College
关键词
间断性缺氧
炎症通路
动脉粥样硬化
Intermittent Hypoxia
Inflammatory pathway
Atherosclerosis
