纳洛酮与无创呼吸机联合在COPD并发呼吸衰竭治疗中的应用分析

Analysis of naloxone combined with noninvasive ventilator in the treatment of elderly patients with chronic obstructive pulmonary disease complicated with respiratory failure

目的研究纳洛酮与无创呼吸机联合治疗老年慢性阻塞性肺疾病(COPD)的疗效。方法老年COPD伴呼吸衰竭患者60例,随机分为观察组与对照组,对照组予以常规治疗,观察组在对照组治疗基础上加用纳洛酮与无创呼吸机联合治疗。结果观察治疗总有效率为93.33%,对照组为66.67%。观察组患者治疗后pH值、氧分压明显高于对照组,二氧化碳分压明显低于对照组;呼吸频率、心率明显低于对照组。结论纳洛酮与无创呼吸机联合,可显著提高老年COPD伴发呼吸衰竭治疗总有效率,明显改善患者血气情况,降低其呼吸频率及心率。

Objective To study the curative effect of naloxone combined with noninvasive ventilation in the treatment of elderly patients with chronic obstructive pulmonary disease. Methods 60 COPD patients complicated with respiratory failure were randomly divided into the observation group and the control group. The control group was given routine treatment, and the observation group was additionally treated with naloxone and noninvasive ventilator therapy. Results The total effective rate was 93. 33% in the observation and 66. 67% in the control group. The im-provement of pH value, oxygen partial pressure, partial pressure of carbon dioxide, respiratory frequency and heart rate was more pronounced in the observation group than in the control group. Conclusion Naloxone combined with noninvasive ventilator can significantly improve the curative effect in the treatment of elderly COPD patients compli-cated with respiratory failure, and reduce the respiratory frequency and heart rate.