不同抗凝药物在COPD合并肺动脉高压中的治疗分析

Analysis of clinical value of different anticoagulant in the treatment of COPD complicated with pulmonary hypertension

目的分析华法林和肝素在COPD合并肺动脉高压治疗中的价值。方法选取在我院进行治疗的COPD合并肺动脉高压的患者72例,根据治疗方法的不同分为两组,分别采用华法林和肝素治疗,对华法林组和肝素组患者的血氧饱和度、氧分压、平均肺动脉压、呼吸困难出现改善的时间和住院时间进行观察。结果华法林组的血氧饱和度和氧分压高于肝素组,而平均肺动脉压低于平均动脉压(P<0.05);华法林组患者的呼吸困难出现改善的时间和住院时间均短于肝素组的患者(P<0.05);华法林组和肝素组患者均无严重不良反应的出现,肝素组出现1例出血过多患者,经保守治疗后治愈。结论华法林能够较肝素更为有效地治疗COPD合并肺动脉高压。

Observation To analyze the clinical value of different anticoagulant in the treatment of COPD with pulmonary hypertension. Methods 72 COPD patients complicated with pulmonary hypertension were divided into two groups according to different therapies. They were conducted warfarin and heparin respectively, then oxygen saturation, oxygen partial pressure, mean pulmonary artery pressure, dyspnea improved time and hospital stay were observed. Results In the warfarin group, oxygen saturation and oxygen partial pressure were higher than those in the heparin group, and the mean pulmonary artery pressure was lower than that in the heparin group. The dyspnea im-proved time and hospital stay was lower in the warfarin group than in the heparin group （P〈0. 05）. There was no se-rious adverse reaction in the two groups. In the heparin group, there was one patient with excessive blood, and he was cured after conservative treatment （P〈0. 05）. Conclusion Warfarin is more effective than heparin does in the treatment of COPD patients complicated with pulmonary hypertension.