青中年咳嗽变异性哮喘患者肺功能及变应原检测分析

Analysis of lung function and allergen detection of young adult patients with cough variant asthma

目的分析青中年咳嗽变异性哮喘患者肺功能及变应原检测结果。方法前瞻性对比观察咳嗽变异性哮喘患者和正常人群FVC%、FEV1%、PEF%、MMEF%、FEF 25%、FEF 50%、FEF 75%、R Occ%指标,体外酶联免疫法检测患者血清变应原抗体。结果两组人群动态肺容积指标中,除FVC%、R Occ%无显著性差异(P>0.05)外,其余FEV1%、PEF%、MMEF%、MEF75%、MEF50%、MEF25%指标中,观察组均低于对照组,两组存在显著性差异(P<0.01);患者血清中发现变应原抗体的31例,占总数的44.93%。结论未经治疗的CVA患者大小气道气流均出现受阻现象,螨虫是诱导本地区青中年人群发生CVA最主要的变应原因素。

Objective To analyze the detection resuhs of lung function and allergen in young adult patients with cough variant asthma. Methods The following indexes were compared between asthma patients and healthy controls, including FVC%, FEV1%, PEF%, MMEF% , FEF25% , FEF50% , FEF75% , and R Occ% targets. Allergen antibody was detected by enzyme-linked immunosorbent. Results There was no significant difference in FVC% and R Oct% between the two groups （P 〉0. 05）, and the rest indicators of FEV1%, PEF%, MMEF% , MEF75% , MEFS0% and MEF25% were obviously lower in the observation group than in the control group （P 〈 0. 01 ）. Serum allergen antibodies were found in 31 cases, accounting for 44.93%. Conclusion There exists airway obstruction phenomenon in patients with untreated CVA, and mites are the major allergen factor causing CVA in young adult population.