胶体金法检测结核抗体的临床价值探讨

Clinical value of colloidal gold in the detection of tuberculosis antibody

目的探讨结核抗体在活动性肺结核中的诊断价值。方法分为活动性肺结核组、非结核疾病组和健康组三组,活动性肺结核组分为痰阳组和痰阴组。均采用胶体金法检测结核抗体。结果计算灵敏度、特异度、假阳性率、假阴性率、约登指数、粗一致性、阳性预测值、阴性预测值8项。痰阳组结核抗体阳性率74.5%,痰阴组阳性率56.0%,P<0.01。结论胶体金法结核抗体在诊断活动性肺结核时有一定参考价值,也可以用于非结核患者和健康体检的初步筛查。

Objective To discuss the clinical value of tuberculosis antibody in the diagnosis of active tuber-culosis. Methods The patients were divided into the active, non-active tuberculosis group and the healthy group, and the active group was further divided into the sputum positive group and the sputum negative group. The tuberculo-sis antibody was detected by colloidal gold method. Results We calculated sensitivity, specificity, false positive rate, false negative rate, Youden index, consistence rate, positive predictive value and negative predictive value. The positive rate of tuberculosis antibody was 74. 5% in the sputum positive group and 56. 0% in the sputum negative group （P〈0. 01）. Conclusion The detection of tuberculosis antibody by colloidal gold is effective in diagnosis of active TB, as well as non-tuberculosis and healthy people.