肼基吡啶类化合物合成

Synthesis of 1-( pyridin-2-yl) hydrazine Derivatives

以氯代吡啶、水合肼等为原料,通过亲核取代反应制备一系列卤代肼基吡啶,其结构由1H NMR,13C NMR进行表征。考察在相同反应条件下,不同氯代吡啶的转化率。指出合成3-氯-5-三氟甲基-2-肼基吡啶收率低的原因是产生了大量副产物5,6-二氯-3-肼基吡啶。

A series of novel 1-（ pyridin-2-yl） hydrazines derivatives were synthesized from chloropyridine,hydrazine hydrate by nucleophilic substitution reactions. Their structures were characterized by1H NMR and13C NMR techniques. The conversion rates of all kinds of chloropyridines were compared under the same reaction conditions. At last,the reason for low yileld of 1-（ 3-chloro-5-（ trifluoromethyl） pyridin-2-yl） hydrazine was due to the formation of by-product 1-（ 5,6-dichloropyridin-3-yl） hydrazine.