豆类食品摄入量对乳腺癌患者预后影响的Meta分析

Relationship between soy food intake and prognosis of breast cancer:a meta-analysis

目的本Meta分析旨在探讨豆类食品摄入量对乳腺癌患者预后的影响。方法参照Cochrance协作网制定的检索策略进行检索，电子数据库包括：MEDLINE（1966～2013年）、WebofScience（1945～2013年）、万方（1998～2013年）和CNKI（1915～2013年）。采用STATA12．0软件进行分析，计算相对危险比（relative ratio，RR）及其95％可信区间（95％con—fidence intervals，95％CI）评价豆类食品摄入量与乳腺癌患者死亡率与复发率的相关性。结果最终6项队列研究符合纳入标准进入本Meta分析，共包括12434例乳腺癌患者，其中3527例患者豆类食品摄入量较低（低摄入量组），5770例患者豆类食品摄入量适中（中摄入量组），1825例患者豆类食品摄入量较高（高摄入量组）。Meta分析结果表明：高摄入量组的乳腺癌患者死亡率明显低于中摄入量组和低摄入量组患者（高摄入量VS．低摄入量，RR=0．41，95％CI=0．19～0．86，P=0．019；高摄入量vs．中摄入量，RR=0．36，95％CI=0．21～0．62，P〈0．001）；此外，高摄入量组的乳腺癌患者复发率亦明显低于中摄入量组和低摄入量组患者（高摄入量Vs低摄入量，RR=0．55；95％CI=0．47～0．65，P〈0．001；高摄入量Vs中摄入量，RR=0．34，95％CI=0．15～0．81，P=0．014）。然而，中摄入量组与低摄入量组乳腺癌患者的死亡率与复发率均无显著统计学差异（均P〉0．05）。结论豆类食品摄入量与乳腺癌患者的预后呈负相关，乳腺癌患者豆类食品摄入量越高，其死亡率与复发率越低。

Objective This study aims to derive a precise estimation of the association between soy food and breast cancer prognosis. Methods An extensive literary search for relevant studies was conducted using the search strategy of Cochrane Collaboration. A range of electronic databases were searched ： MEDLINE （ 1966 - 2013 ） , Web of Science （ 1945 - 2013 ） , WanFang （ 1998 2013） and CNKI（ 1915 -2013）. The meta-analysis was then performed using the STATA 12. 0 software. Crude relative ratio（RR） with their 95% confidence interval （CI） were calculated. Results Six cohort studies were included with a total of 12,434 breast cancer patients,including 3,527 patients in the lowest intake group,5,770 patients in the median intake group and 1,825 patients in the highest intake group. Our study results revealed that soy food intake was significantly associated with mortality and recurrence of breast cancer patients. We found that the mortality of patients in the highest intake group was significantly lower than patients in median and lowest groups. （highest intake vs. lowest intake：RR = 0. 41,95% CI = 0. 19 -0. 86 ,P = 0. 019 ;highest intake vs. median intake, RR = 0. 36,95% CI = 0. 21 -0. 62 ,P 〈 0. 001 ） ;Furthermore,the recurrence of breast cancer patients with the highest soy food intake was significantly lower than patients in median and lowest groups （highest intake vs. lowest intake：RR = 0. 55,95% CI = 0. 47 0. 65,P 〈 0. 001 ; highest intake vs. median intake ： RR = 0. 34,95% CI = 0. 15 - 0. 81, P = 0. 014 ）. However, similar associations are not observed between the median intake and the lowest intake （ all P 〉 0. 05 ）. Conclusion Our study revealed that high soy food consumption may reduced the mortality and recurrence of breast cancer patients, and the more soy food intake,the lower mortality and recurrence of breast cancer patients was.