瑞舒伐他汀对原发性高血压患者颈动脉粥样硬化影响及临床疗效观察

Red easy cutting statin EH patients to CAS effects and clinical curative effect observation

目的通过观察瑞舒伐他汀治疗原发性高血压(EH)患者颈动脉内膜中层厚度(CAIMT)、血脂及血压水平变化,探讨瑞舒伐他汀对EH患者颈动脉粥样硬化(CAS)的影响以及临床疗效观察。方法以128例EH患者为研究对象,治疗前后监测CAIMT值、血压及血脂,CAIMT值的测量采用彩色多普勒超声仪,据CAIMT值分组后采用常规及察瑞舒伐他汀治疗,治疗6个月后观察其临床疗效。结果①128例EH患者中79例CAIMT值>1.0mm(61.72%)为内膜增厚。②两组患者治疗前血脂水平差异无显著性(P>0.05)。治疗(6个月)后,CAIMT增厚组(瑞舒伐他汀治疗)的血脂水平变化有显著性(P<0.01),CAIMT值显著降低(P<0.01);常规治疗的CAIMT非增厚组无显著性变化(P>0.05),但CAIMT值显著升高(P<0.01)。③瑞舒伐他汀治疗的CAIMT增厚组的显效率和总有效率(73.4%,93.7%)均显著高于CAIMT非增厚组(47.0%,65.4%)(P<0.01)。结论瑞舒伐他汀可通过改善EH患者血脂水平及血管内皮细胞功能来改善或控制动脉粥样硬化的发生发展,提高临床疗效。

Objective To investigate the changes of red easy cutting statin therapy in patients with EH CAIMT and blood fat and blood pressure level, and study the effect of red easy cutting statin EH patients to the influence of CAS, and clinical observation. Methods Select 128 cases of EH patients as the research object,before and after treatment CAIMT monitoring value and blood pressure and blood fat, CAIMT value is measured by color doppler ultrasound instrument, according to CAIMT value after the group with normal and ChaRui easy cutting statin therapy, treatment for 6 months after observe the clinical curative effect. Results 128 patients with EH patients in 79 cases of CAIMT 〉 1.0mm（61.72% ） for endometrial thickening. The two groups before treatment blood lipid level has no significant difference（ P 〉 0. 05 ）. Treatment for 6 months later, he cut shu statin treatment CAIMT thickening group have significant change（P 〈 0. 01 ）, CAIMT value significantly reduced（ P 〈 0. 01 ）. Conventional treatment CAIMT non thickening group has no significant change （ P 〉 0. 05 ）, but CAIMT value （ P 〈 0. O1 ）. Red easy cutting statin treatment CAIMT thickening group of significant efficiency and the total effective rate （ 73.4% , 93.7% ） were significantly higher than CAIMT thickening group （47. 0% ,65.4% ） （P 〈 0. 01 ）. Conclusion Red easy cutting statin can through the improvement of EH patients blood lipid level and vascular endothelial cell function to improve or control the occurrence of atherosclerosis development, improve the clinical effect.