盐酸二甲双胍片对2型糖尿病神经病变患者氧化应激的作用

Exploration of the role of metformin hydrochloride on oxidative stress of patients with type 2 diabetic neuropathy

目的评价盐酸二甲双胍片对2型糖尿病神经病变患者治疗效果及氧化应激反应的影响。方法选取我院2008-05—2013-02收治的90例2型糖尿病神经病变患者按照随机数字表法分为治疗组与对照组各45例,治疗组给予盐酸二甲双胍片+甲钴胺片治疗,对照组给予那格列奈片+甲钴胺片治疗,疗程均为3个月,比较2组患者的临床疗效、神经病变改善程度及氧化应激指标变化。结果治疗3个月后,治疗组总有效率显著高于对照组(χ2=8.421,P<0.01);2组患者治疗前FBG、PBG、HbAlc血糖指标、MNCV、SNCV神经传导指标、MDA、SOD及TAOC氧化应激指标比较差异均无统计学意义(P>0.05),治疗3个月后治疗组较治疗前、同期对照组比较差异有统计学意义(P<0.05)。结论盐酸二甲双胍片可明显改善2型糖尿病神经病变患者机体氧化应激状态,有利于降低血糖、改善临床症状体征、提高神经传导速度。

Objective To evaluate the effect of metformin hydrochloride on the treatment of patients with type 2 diabetic neuropathy and it influence on oxidative stress. Methods Ninety patients with type 2 diabetic neuropathy from May 2008 to February 2013 in our hospital were selected ,according to random number table method they were randomly divided into treat-ment group and control group ,with 45 cases in each group.the treatment group were given metformin and mecobalamin ,the control group were given nateglinide and mecobalamine ,the course was 3 months ,the clinical efficacy ,the degree of improve-ment of neuropathy and the changes of oxidative stress index of two groups were compared.Results After 3 months of treat-ment ,the total effective rate of treatment group was significantly higher than that of the control group （χ2 =8.421 ,P〈0.01）;before treatment ,blood sugar index such as FBG ,PBG ,HbAlc ,the index of nerve conduction MNCV ,SNCV ,the index of oxidative stress MDA ,SOD and TAOC of two groups showed no significant difference （P〉0.05）.After 3 months of treat-ment ,the indexes mentioned above ,had significant differences comparing with those of before treatment and those of control group in the same period （P〈 0.05） ,with statistical significance.Conclusion Metformin can obviously improve neuropathy and oxidative stress of the type 2 diabetic patients ,reduce blood sugar ,improve the clinical symptoms and signs ,and promote nerve conduction velocity.