维生素B_(12)与腔隙性梗死后抑郁的相关性分析

Study on the association of Vitamin B_(12) and depression secondary to lacunar cerebral infarction

目的对维生素B12与腔隙性梗死后抑郁存在的相关性进行探讨。方法将我院2011-01—2013-01收治的腔隙性梗死患者798例分为对照组708例与观察组90例,对照组无抑郁症,观察组存在抑郁症(根据汉密尔顿抑郁量表判定),对比并分析2组患者的维生素B12水平。结果对照组血清维生素B12平均浓度为(178.6±20.7)pmol/L,维生素B12缺乏197例(27.9%),观察组,血清维生素B12平均浓度(141.7±19.7)pmol/L,维生素B12缺乏60例(66.7%),2组比较差异均有统计学意义(P<0.05)。结论维生素B12缺乏与腔隙性梗死后抑郁存在着相关性,腔隙性梗死并抑郁患者的维生素B12水平较普通腔隙性梗死患者更低,维生素B12缺乏情况较为明显,在治疗过程中适当补充维生素B12可以让患者的抑郁症状得到缓解,并可提升腔隙性梗死的治疗效果,促进患者恢复。

Objective To investigate the relevance between vitamin B12 and depression after lacunar cerebral infarc-tion.Methods Seventy hundred and ninety-eight patients with lacunar cerebral infarction admitted to our hospital from January 2011 to January 2011 were divided into control group（708 cases） and observation group （90 cases） ,no depression in control group patients ,the observation group patients had depression （judged according to the Hamilton depression rating scale ） ,vita-min B12 levels of patients in the two groups were analyzed and compared.Results The mean concentration of serum vitamin B12 of the control group was（178.6 ± 20.7）pmol/L ,the number of patients with vitamin B12 deficiency was 197 ,the ratio of which was 27.9% ;In the observation group ,the mean concentration of serum vitamin B12 was（141.7 ± 19.7）pmol/L ,the number of patients with vitamin B12 deficiency was 60 ,the ratio of which was 66.7%.The difference between the two groups had statisti-cal significance （P〈0.05）. Conclusion There is correlation between vitamin B12 deficiency and depression after lacunar cere-bral infarction ,patients with lacunar cerebral infarction and depression have lower levels of vitamin B 12 than those with ordinary lacunar infarction ,vitamin B12 deficiency is more obvious. In the process of treatment ,appropriate supplement of vitamin B12 can make patients get alleviating symptoms of depression ,improve the therapeutic effect of lacunar cerebral infarction ,and pro-mote the recovery of patients.