非典型抗精神病药物对女性精神分裂症患者泌乳素水平的影响

Influence of atypical antipsychotics on the level of prolactin in female schizophrenia

目的：探讨非典型抗精神病药物对女性精神分裂症泌乳素的影响。方法选择18～45岁女性精神分裂症住院患者，随机分为奥氮平组、利培酮组、喹硫平组、阿立哌唑组，每组30例。于治疗开始第0、4、8周检测血清泌乳素。并记录月经、溢乳等情况。结果与治疗前相比，奥氮平组及利培酮组患者的血清泌乳素水平升高（P＜0.01），随着治疗时间的延长利培酮组患者的泌乳素水平明显升高，并有相应的临床症状；喹硫平组及阿立哌唑组患者的血清泌乳素水平无明显升高。结论奥氮平和利培酮均可引起血清泌乳素水平升高，并出现月经延迟、溢乳等症状。喹硫平及阿立哌唑对血清泌乳素无影响。

Objective To investigate the influence of atypical antipsychotics on the level of prolactin in female schizophre-nia.Methods 18 to 45 years old female patients with schizophrenia in hospital were randomly allocated to four groups treated with olanzapine ,risperidone ,quetiapine and aripiprazole respectively ,30 cases in each group. Prolactin were measured at base-line and after 4 ,8 weeks of treatment respectively ,with menstruation and spilled milk recorded. Results The level of prolactin was increased in both olanzapine and risperidone groups （P〈 0.01） ,especially in risperidone group as the treatment contin-ues. There was no significant difference between quetiapine and aripiprazole group. Conclusion Both olanzapine and risperi-done can increase the level of prolactin ,while either quetiapine or aripiprazole has no effect on the level of serum prolactin.