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VEGFs/VEGFR在宫颈癌中的研究进展

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摘要 宫颈癌是全球妇女中仅次于乳腺癌的恶性肿瘤，淋巴道转移是宫颈癌侵袭远处器官的主要途径之一，而宫颈癌的高病死率与淋巴结转移密切相关。肿瘤组织边缘微淋巴管是肿瘤细胞进入淋巴系统的主要门户，恶性肿瘤细胞主要是通过其周边组织的微淋巴管进入淋巴系统转移的。近年研究表明，VEGF及其家族成员不单在肿瘤血管生成，在微淋巴管生成中也是必不可少的诱导因子。本文综述对VEGF及受体与宫颈癌的病理分级、临床分期、转移、预后及治疗等关系的研究进展。
作者 国宏莉 李江华 徐臣利
机构地区 湖北医药学院病理学教研室 湖北医药学院附属人民医院病理科 湖北医药学院附属太和医院显微整形外科
出处 《贵州医药》 CAS 2014年第3期276-278,共3页 Guizhou Medical Journal
基金 湖北省教育厅基金项目(B2013122) 十堰市科技局基目(ZD2011029)
关键词 宫颈癌 恶性肿瘤细胞 淋巴道转移 肿瘤血管生成 淋巴系统 微淋巴管 VEGF 淋巴结转移
分类号 R737.33 [医药卫生—肿瘤]
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参考文献17

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二级参考文献7

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共引文献7

贵州医药
2014年 第3期

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