他汀类药物的临床应用

Clinical application of statins

他汀类药传统上是作为调脂药应用的,4S研究确立了他汀类药在心脑血管病中治疗及预防的地位,并形成调脂外多功能效应的理论。冠心病患者在心血管病事件后,β受体阻滞剂及阿司匹林各降低心血管病病死率25%,而他汀类药物治疗,可降低42%,作用强度最大,被誉为＂心脏药物＂〔1〕。经20余年临床实践,治疗适应症不断拓宽,有多种疾病能在治疗中获益且安全可靠。为更好地应用他汀类药物,将有关问题综述如下。

Statins are traditionally applied as a lipid-lowering drug,4 Sstudy established the position of statins in heart and brain disease treatment and prevention,and the formation of multi-functional theory beyond lipid lowering effects.CHD patients after heart disease events,β-blockers and aspirin to reduce cardiovascular disease mortality for each 25%,while statin therapy,can reduce by 42%,the role of the maximum intensity,known as the ＂heart medicine＂ After 20 years of clinical practice,therapeutic indications continue to expand,there are a variety of diseases can benefit from a reliable and safe in the treatment.