摘要
磷脂酶A2(phospholipase A2,PLA2)是一类能够催化脂蛋白和细胞膜上的甘油磷脂二位酰基酯键,水解形成包括花生四烯酸在内的游离脂肪酸和溶血磷脂的酶族[1]。到目前为止,至少已报道了19种不同的PLA2[2]。根据其催化活性对钙离子的需要程度。
出处
《现代临床医学》
2014年第2期96-99,共4页
Journal of Modern Clinical Medicine
基金
国家自然科学基金(No.81101679)
参考文献29
-
1Six DA, Dennis EA. The expanding superfamily of phospholipase A2 enzymes: classification and characterization [J]. Biochim Biophys Acta, 2000, 1488(1 - 2) : 1 - 19.
-
2Akiba S, Sato T. Cellular function of calcium - independent phospholipase A2 [J]. Biol Pharm Bull, 2004, 27 ( 8): 1174 -1178.
-
3Kovanen PT, Pentikainen MO. Secretory group II phospholipase a2 a newly recognized Acute - Phase reactant with a role in atherogenesis [J]. Circ Res, 2000, 86 ( 6) : 610 -612.
-
4Hanasaki K, Arita H. Biological and pathological functions of phospholipase A2 receptor[J]. Arch Biochem Biophys, 1999, 372(2): 215 -223.
-
5Ancian P, Lambeau G, Mattei M G, et al. The human 180 - kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization [J]. J BioI Chern, 1995, 270 ( 15) : 8963 -8970.
-
6Zvaritch E, Lambeau G, Lazdunski M. Endocytic properties of the m - type 180 - kDa receptor for secretory phospholipases a [J]. J BioI Chern, 1996, 271 (1) : 250 - 257.
-
7Acosta JC, 0' loghlen A, Banito A, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence [J] . Cell, 2008, 133 (6): 1006 - 1018.
-
8Augert A, Payre C, De Launoit Y, et al. The M - type receptor PLA2R regulates senescence through the p53 pathway [J]. EMBO Rep, 2009, 10 ( 3) : 271 - 277.
-
9Fonteh AN, Atsumi G, Laporte T, et al. Secretory phospholipase A2 receptor - mediated activation of cytosolic phospholipase A2 in murine bone marrow - derived mast cells [J]. J Immunol, 2000,165(5): 2773 -2782.
-
10Muralikrishna AR, Hatcher JF. Phospholipase a2, reactive Oxygen species, and lipid peroxidation in cerebral ischemia [J]. Free Radic Biol Med, 2006, 40 (3) : 376 - 387.
同被引文献24
-
1Kessentini - Zouari R, Jebali J, Taboubi S, et al. CC - PLA2 - 1 and CC - PLA2 - 2, two Cerastes cerastes venom - derived phos- pholipases A2, inhibit angiogenesis both in vitro and in vivo [ J ]. Lab Invest, 2010, 90(4) : 510 -519.
-
2Yagami T, Yamamoto Y, Okamura N, et al. L - type voltage - dependent calcium channel is involved in the snake venom group I A secretory phospholipase A2 -induced neuronal apoptosis [ J ]. Neurotoxicology, 2013, 35 : 146 - 153.
-
3Yagami T, Yamamoto Y, Koma H. The role of secretory phospho- lipase A(2) in the central nervous system and neurological disea- ses[J]. Mol Neurobiol, 2014, 49(2) : 863 -876.
-
4DeCoster MA. Group NI secreted phospholipase A2 causes apopto- sis in rat primary cortical neuronal cultures[ J]. Brain Res, 2003, 988(1/2) : 20 -28.
-
5Nyegaard S, Novakovic VA, Rasmussen JT, et al. Lactadherin in- hibits secretory phospholipase A2 activity on pre - apoptotic leuke- mia cells[J]. PLoS One, 2013, 8(10) : e77143.
-
6Toyama DO, Gaeta HH, de Pinho MV, et al. An evaluation of 3 - rh- amnosylquercetin, a glycosylated form of quereetin, against the myotoxic and edematogenie effects of sPLA 2 from Crotalus durissus terrifieus[ J]. Biomed Res Int, 2014, 2014: 341270.
-
7Murakami M, Taketomi Y, Sato H, et al. Secreted phospholipase A2 revisited[J]. J Bioehem, 2011, 150(3) : 233 -255.
-
8Murakami M, Lambean G. Emerging roles of secreted phospho- lipase A(2) enzymes: an update[J]. Biochimie, 2013, 95( 1 ) : 43 - 50.
-
9Vulfius CA, Kasheverov IE, Starkov VG, et al. Inhibition of nico- tinic acetylcholine receptors, a novel facet in the pleiotropic activi- ties of snake venom phospholipases A2 [ J ]. PLoS One, 2014, 9 (12) : e115428.
-
10Shiyu S, Zhiyu L, Mao Y, et al. Polydatin up - regulates Clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro[ J ]. B MC Cell Bial, 2011, 12: 31.
-
1林文珍,舒雨雁,周元聪.蛇毒磷脂酶A_2的研究[J].现代临床医学生物工程学杂志,2002,8(6):397-402. 被引量:2
-
2吴国球,高茂馗,钱娟英,王喜红.通过维生素D_(3)结合蛋白介导的溶血磷脂对人外周巨噬细胞的激活作用[J].南京铁道医学院学报,1999,18(3):176-178.
-
3医学遗传学[J].国外科技资料目录(医药卫生),1998(12):13-14.
-
4吴静,刘伟敬,刘华锋.磷脂酶A2及其M型受体的研究进展[J].中国伤残医学,2014,22(15):215-216.
-
5吴国球,高茂馗,何岳文.维生素D3结合蛋白对人单核细胞的激活作用[J].上海免疫学杂志,2000,20(1):52-53.
-
6常诚,宋京翔,王烈,涂小煌.间充质干细胞及其作用的研究新进展[J].国际外科学杂志,2011,38(5):331-334. 被引量:1
-
7传良敏,李萍,黄文方.钙非依赖型磷脂酶A_2活性的调节及生物学功能[J].国际检验医学杂志,2006,27(4):373-375. 被引量:1
-
8张艳,梁标.磷脂酶A_2的调节机制[J].吉林医学,2005,26(12):1374-1376. 被引量:4
-
9谢保同.胞内磷脂酶A_2及其抑制剂[J].蛇志,2001,13(2):61-66. 被引量:1
-
10缪明永.肿瘤脂类异常代谢的研究进展[J].中国医学前沿杂志(电子版),2016,8(1):15-19.