影响深Ⅱ度烧伤及手术切口伤瘢痕增生的多因素分析

Multivariate analysis in scar proliferation after deep-partial thickness burn and surgical operation

目的对影响深Ⅱ度烧伤及手术切口缝合伤瘢痕增生的多种可能因素进行相关性分析。方法对我国6个地区深Ⅱ度烧伤及手术切口伤共1090例患者伤后3、6、12个月三个时相点的瘢痕增生程度进行定量测定,对伤后时间、性别、年龄、民族、婚姻状态、饮酒吸烟嗜好、辛辣饮食习惯、家族史和过敏史资料与瘢痕增生程度进行相关性分析。结果多元逐步回归分析显示民族、性别、年龄、辛辣饮食及饮酒习惯与瘢痕增生程度有相关性。其中性别和年龄与瘢痕增生程度呈负相关:女性瘢痕略轻,年龄越大瘢痕增生越轻;饮酒及辛辣饮食与瘢痕增生程度呈正相关,有饮酒及辛辣饮食习惯的瘢痕明显;不同民族瘢痕增生程度亦有显著差异。而伤后时间、婚姻状况、吸烟与否、家族史、过敏史与瘢痕增生程度的相关性不显著。结论深Ⅱ度烧伤及手术切口伤的瘢痕增生程度与患者民族、性别、年龄及饮食习惯密切相关。伤后1年内瘢痕增生未见明显消退,提示伤后抗瘢痕治疗十分重要。

Objective To observe the risk factors of scar proliferation among patients with deep-partial thickness burn and surgical suture wound.Methods Objective scar measurement （by negative-positive moulage） was carried out at 3,6 and 12 months after wound healing in 1090 patients from different regions in China.The following data were studied：post-injury time,gender,age,nationality,marital status,alcohol drinking,smoking,pungent food habits,family history,hypersensitivity.Results Multiple regression analysis revealed that nationality,gender,age,alcohol drinking and pungent food habits were the important risk factors related to scar proliferation.Gender and age were inversely correlated to scar proliferation.Scar was less obvious in female and old people.Alcohol drinking and pungent food habits were positively correlated to scar proliferation degree.Nationality was also found relative to scar proliferation.Conclusions Individual characteristic （nationality,gender,age） and food habits are closely related to scar proliferation.Scar atrophy was not occur obviously after one year postinjury,so it＇s important to take anti-scar therapy after wound healing.