淫羊藿苷神经保护作用机制研究进展

Adances in neuroprotective effects mechanisms of Icariin

淫羊藿苷是中药淫羊藿的主要活性成分,具有抗肿瘤、增强免疫、改善心脑血管、调节内分泌等多重药理学作用。近年来关于淫羊藿苷对中枢神经系统保护作用的研究日益增多,为了进一步推进淫羊藿苷对于防治中枢神经系统疾病的研究,本文结合近十年国内外对其保护神经元细胞的研究报道,系统地总结和陈述了淫羊藿苷发挥保护神经作用的几个途径,主要包括抗氧化应激、抑制炎症反应、影响单胺类递质及氨基酸类神经递质的释放、增加神经营养作用等几个方面,以及探讨了淫羊藿苷发挥神经保护作用的信号转导机制,为进一步推进淫羊藿苷的研究作出理论支持。

Icariin is one of the most dynamic composition of Epimedium, which has pharmacologi-cal functions of inhibiting tumor, enhancing immunity, improving heart and cerebral vessels, and regulating endocrine function. In recent years,researches on neuroprotective effects of icariin in central nervous sys-tem have been increased . To further promote the researches on prevention and cure on central nervous sys-tem diseases,this review systematically summarizes the neuroprotective effects of icariin on neurons inclu-ding the mechanism combined with research reports of Icariin at home and abroad, which include the fol-lowing, antioxigenic stess, inhibiting the inflammatory response, adjusting the release of neurotransmitter of monoamines and amino acids, and increasing neurotrophic effect. The signal transduction mechanism of icariin’s neuroprotective effect is also discussed, which may provide useful theoretical support to the re-search of icariin.