人参皂苷Rg3抗宫颈癌作用机制的研究进展

Research progress on mechanism of ginsenosides Rg3 against cervical cancer

宫颈癌是妇科最常见的恶性肿瘤,目前临床使用的治疗方法均有副作用。随着医药学的发展,天然药物在宫颈癌疗效、治疗靶点方面的优势越来越受到研究者的重视。国内外实验研究以及流行病学调查均表明传统的滋补养生名贵中草药人参的主要活性成分人参皂苷Rg3在抗宫颈癌方面有有效的作用,也有研究发现其能使化疗增敏。为进一步系统的了解人参皂苷Rg3在治疗宫颈癌方面的作用,本文从促进宫颈癌细胞凋亡,抑制宫颈癌细胞增殖,抑制宫颈癌新生血管形成以及提高免疫力等几个方面对人参皂苷Rg3抗宫颈癌作用机制进行综述。

Cervical cancer is the most common malignant gynecological tumor in Gynecology. Cur-rent clinical treatment methods all have worrying side effects. With the rapid development of biomedicine and pharmacy, the advantages of natural medicine in the treatment of cervical cancer therapeutic target has been attached more and more importance by researchers. Ginseng is a traditional Chinese tonic herb which is rare and luxury. At present, domestic/ overseas experimental research and epidemiological investigation all show that the main active ingredients named Rg3 has an effective role in anti cervical cancer. There are also some other studies that show that Ginsenoside Rg3 can play the role of chemotherapy sensitization. For further understanding of ginsenoside Rg3 in the treatment of cervical cancer, this paper, reviews the mech-anism of Ginsenoside Rg3 against cervical cancer as follows：Ginsenoside Rg3 can promote the apoptosis of cervical cancer cells, inhibit the proliferation of cervical cancer cells, promote the inhibition of cervical＆nbsp;carcinoma angiogenesis, and improve the immunity of patients and so on.