雌激素相关基因多态性与非吸烟女性肺癌关系

Polymorphisms of estrogen related genes and susceptibility of non-smoking female lung cancer

目的探讨雌激素合成和代谢相关基因多态性与非吸烟女性肺癌易感性的关系，为女性肺癌研究提供新的遗传易感性标志。方法采用以医院为基础的病例对照研究方法，抽取辽宁省沈阳市某三级甲等医院2004年1月—2012年12月收治的516例汉族非吸烟女性肺癌患者和同期收治的516例非呼吸系统疾病且非肿瘤汉族非吸烟女性患者分别作为病例组和对照组进行问卷调查和基因分型。结果校正年龄和油烟暴露因素后，rs4680位点携带G／A基因型的个体患肺癌的风险较携带G／G野生纯合基因型个体增加了60％（OR：1．60，95％CI=1．23～2．08）；携带G／A或A／A的个体患肺癌的风险较携带G／G野生纯合基因型个体增加了57％（OR=1．57，95％CI=1．22～2．01）；rs743572、rs10046和rs605059位点的多态性与肺癌的患病风险均无显著性关联。结论COMT基因rs4680位点多态性可能是中国汉族非吸烟女性肺癌发病的潜在遗传易感性标志。

Objective To explore the relationship between polymorphisms of estrogen synthesis and metabolism re- lated genes and susceptibility of non-smoking female lung cancer and to provide new genetic susceptibility markers for fe- male lung cancer research. Methods A hospital based case-control study was conducted. Totally 516 unrelated Han non- smoking females with lung cancer and 516 unrelated Han non-smoking females with diseases other than respiratory sys- tem disease and tumor were selected as a case group and a control group, respectively, from a level 3 first-class hospital in Shenyang, Liaoning province from January 2004 to December 2012. Questionnaire survey and genotyping were conducted to study the relationship. Results The risk of lung cancer increased by 60% for individuals carrying G/A genotype than those carrying wild homozygous G/G genotype of rs4680 after adjusting for age and cooking smoke exposure（ odds ratio （OR） = 1.60,95% confidence interval（95% CI） 1.23 - 2. 08 ） ;the risk of lung cancer increased by 57% for individuals carrying G/A or A/A genotype than those carrying wild homozygous G/G genotype（ OR = 1.57,95% CI： 1.22 -2. 01 ）. No significant correlation was found between rs743572, rs10046 and rs605059 polymorphism and risk of lung cancer. Conclusion Polymorphism of rs4680 of catechol-O-methytransferase may be a potential genetic susceptibility loci of lung cancer for Han non-smoking women in China.