高血浆同型半胱氨酸与脑梗死关系的临床研究

Correlational study of the hyperhomocysteine and cerebral infarction

目的研究同型半胱氨酸与脑梗死的相关性,为脑梗死的防治提供依据。方法选择在我院神经内科住院的脑梗死患者200例作为观察组,并选择同期在我院行健康体检者100例作为对照组,其中观察组依NIHSS评分再分轻、中、重度脑功能缺损组,采用全自动生化分析仪检测研究对象血浆同型半胱氨酸水平,并进行分析和比较。结果观察组血浆同型半胱氨酸为(19.01±2.31)μmol/L、对照组为(11.23±2.91)μmol/L,两组比较差异具有统计学意义(P<0.05)。轻、中、重度脑功能缺损组血浆同型半胱氨酸水平分别为(14.82±3.22)μmol/L、(18.21±3.14)μmol/L、(23.99±4.05)μmol/L,不同脑功能缺损程度组间血浆同型半胱氨酸比较差异具有统计学意义(P<0.05)。结论血浆同型半胱氨酸水平可能与脑梗死的发生、发展相关,血浆同型半胱氨酸浓度测定对脑梗死患者病情严重程度的判断有一定的指导意义。

Objective To study the relativity between hyperhomocysteine and cerebral infarction, provid scientific basis for prevention and treatment. Methods 200 patients with cerebral infarction （observation group） and 100 health people （control group） were selected,the patients in the observation group were sub-diveded into the mild, the moderate, the severe group according to NIHSS score, the level of plasma homocysteine was detected by automatic biochemical analyzer and analysed. Results The level of plasma homocysteine in the observation group [ （ 19.01±2.31 ）μmol/L] was significantly higher compared with the control group [（11. 23±2. 91）vLmol/L] （P 〈 0. 05）. The level of plasma homocysteine in the mild, moderate, severe group were （ 14.82 ± 3.22）, （ 18.21± 3.14 ）, （23.99± 4.05 ）μmol/L, respectively, there was significant difference among these 3 groups （P 〈 0.05）. Conclusion The level of plasma homoeysteine might relate to the oeeurrence and development of cerebral infaretion, determination of plasma homoeysteine concentration could be help to judge the severity of cerebral infarction.