血尿酸和5-羟色胺水平与青少年抑郁症发病机制的关系

High serum uric acid level in adolescent depressive patients

目的研究青少年抑郁症患者血尿酸和5-羟色胺水平,探索青少年抑郁症的发病机制。方法对青少年抑郁症患者(病例组)和健康青少年(对照组)各106例进行血尿酸水平检测,对41例抑郁症患者的5-羟色胺水平进行分析。结果病例组血尿酸为(435.61±101.36)μmol/L,高于对照组(332.73±63.52)μmol/L,差异有统计学意义(t=8.86,P<0.001)。病例组中高血尿酸者51例,占48.11%;病例组5-羟色胺水平显著低于全国常模(P=0.005),并与血尿酸水平显著负相关(r=-0.48,P<0.01)。结论高血尿酸可作为青少年抑郁症早期诊断的一个指标,青少年抑郁症可能是由于脑内神经元DNA氧化损伤所致。

Objective To study the pathogenesis of adolescence depression through the assay of serum uric acid （SUA） and 5-HT level in adolescent depressive patients. Methods Forty-one depressive patients under analysis of serum SHT levels. Results The serum uric acid leveling the study group （435.61 ± 101.36） μmol/L was higher than that in control group （332.73 ± 63.52）μmol/L; the difference was statistically significant （t = 8.86, P 〈 0. 001 ）. In the study group, there were in 51 cases of hy- peruricemia, accounting for 48.11%. In the study group, the significantly lower were serotonin levels than that of national norm （ P = 0. 005 ）, and were significantly negatively correlated with the blood uric acid levels （ r = - 0.48, P 〈 0.01 ）. Conclusions High level of SUA can be used as a biochemical index for the early diagnose of adolescence depression; adolescence depression may be due to DNA oxidative damage of neurons in the brain.