冠心病患者C反应蛋白、血同型半胱氨酸水平改变意义

Significance of C-reactive protein, homocysteine levels change in patients with coronary heart disease

目的探讨冠心病患者C反应蛋白、血同型半胱氨酸水平改变意义。方法选择本院收治的冠心病患者共248例,作为冠心病组,其中稳定型心绞痛患者共80例、不稳定型心绞痛患者共104例、急性心肌梗死患者64例,上述患者分别作为稳定型心绞痛组、不稳定型心绞痛组、心肌梗死组。同时选择健康者作为对照组。采用免疫比浊法测定C反应蛋白水平,采用循环酶法来测定血同型半胱氨酸含量改变情况。结果冠心病组的C反应蛋白、血同型半胱氨酸水平高于对照组,差异有统计学意义(P<0.05);急性心肌梗死组的C反应蛋白、血同型半胱氨酸水平高于不稳定型心绞痛组,差异有统计学意义(P<0.05);不稳定型心绞痛患者C反应蛋白、血同型半胱氨酸水平高于稳定型心绞痛组,差异有统计学意义(P<0.05)。结论冠心病患者的C反应蛋白、血同型半胱氨酸水平升高,其水平升高有助于了解冠心病病情严重程度。

Objective To explore the significance of C-reactive protein, homocysteine levels change in patients with coronary heart disease. Methods 248cases with coronary heart disease in our hospital were selected as the coronary heart disease group. In the patients, 80 patients with stable angina, 104 patients with unstable angina, 64 patients with acute myocardial infarction , the patients were divided into stable angina group, unstable angina group, myocardial infarction group. The healthy persons were selected as the control group.C reaction protein level was determined by immune turbidimetry, homocysteine content changes was determined by enzymatic cycling method.Results C reactive protein, blood homocysteine levels in coronary heart disease group were higher than those in the control group, the difference was statistically significant （P＆lt;0.05）;C reactive protein, blood homocysteine levels in acute myocardial infarction group were higher than those in unstable angina group, the difference was statistically significant （P＆lt;0.05）;C reactive protein, blood homocysteine levels in unstable angina group were higher than those in stable angina group, the difference was statistically significant （P＆lt;0.05）. Conclusion The levels of C reactive protein and homocysteine in patients with coronary heart disease is high, the elevated levels are helpful to understand the severity of coronary artery disease.