摘要
Objective: The purpose of the study was to study the mechanism of vasculogenic mimicry(VM) and its relationship with tumor stage in non-small cell lung cancer(NSCLC). Methods: Forty-two patients with NSCLC were collected, 19 belonged to the early stage(stages I + II) while 23 were late stage(stages III + IV). Moreover, 20 patients got surgical treatment and 22 got chemotherapy. We studied the relationship of VM with stage, chemotherapeutic effect, HIF-1α, microvessel density(MVD) and clinicopathologic features. Results: VM in patients of early stages were significantly more than late stages(68.4% vs 26.1%, P = 0.006), and the positive rate of VM was proportional to HIF-1α(P = 0.034). But no correlation was found between VM and chemotherapeutic effect(14.3% vs 26.7%, P = 1.00) or MVD(P > 0.05). Furthermore, we found VM also showed a negative correlation with distant metastases and lymph nodes metastases(P < 0.05) while no correlation was found with other clinicopathologic. Conclusion: VM was generated during the early stage in NSCLC and correlated with lymph nodes metastases. As the disease progressed, VM may be replaced by vascular endothelial cells, so the late-stage patients especially people with distant metastases had fewer VM. As the main factor produced by hypoxia, HIF-1α may make a difference in VM formation. Thus we inferred VM might be a new target for targeted therapy, and could provide help for clinical staging and treatment.
Objective： The purpose of the study was to study the mechanism of vasculogenic mimicry （VM） and its relationship with tumor stage in non-small cell lung cancer （NSCLC）. Methods： Forty-two patients with NSCLC were collected, 19 belonged to the early stage （stages Ⅰ ＋Ⅱ） while 23 were late stage （stages Ⅲ ＋ Ⅳ）. Moreover, 20 patients got surgical treat ment and 22 got chemotherapy. We studied the relationship of VM with stage, chemotherapeutic effect, HIF-la, microves sel density （MVD） and clinicopathologic features. Results： VM in patients of early stages were significantly more than late stages （68.4% vs 26.1%, P = 0.006）, and the positive rate of VM was proportional to HIF-la （P = 0.034）. But no correlation was found between VM and chemotherapeutic effect （14.3% vs 26.7%, P = 1.00） or MVD （P 〉 0.05）. Furthermore, we found VM also showed a negative correlation with distant metastases and lymph nodes metastases （P 〈 0.05） while no correlation was found with other clinicopathologic. Conclusion： VM was generated during the early stage in NSCLC and correlated with lymph nodes metastases. As the disease progressed, VM may be replaced by vascular endothelial cells, so the late-stage patients especially people with distant metastases had fewer VM. As the main factor produced by hypoxia, HIF-la may make a difference in VM formation. Thus we inferred VM might be a new target for targeted therapy, and could provide help for clinical staging and treatment.
