摘要
Objective: Exploring the clinical signification of high-mobility group box 1 protein(HMGB1) expression in infiltrating ductal carcinoma(IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2(HER-2) were also analyzed. Results: Fortysix cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression(76.67%), statistical significance was observed between HMGB1 expression with clinical staging(P < 0.01), lymph node metastasis(P < 0.01), breast cancer ER(P < 0.05) and HER-2(P < 0.05), however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression(P > 0.05) in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion: It's promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis.
Objective： Exploring the clinical signification of high-mobility group box 1 protein （HMGB1） expression in infiltrating ductal carcinoma （IDC） breast tissue. Methods： The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor （ER）, progesterone receptor （PR） and human epidermal growth factor receptor 2 （HER-2） were also analyzed. Results： Forty six cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression （76.67%）, statistical significance was observed between HMGB1 expression with clinical staging （P 〈 0.01）, lymph node metastasis （P 〈 0.01）, breast cancer ER （P 〈 0.05） and HER-2 （P 〈 0.05）, however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression （P 〉 0.05） in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion： It＇s promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis.
基金
Supported by a grant from the Innovation Foundation of Excellent Intellectuals in Henan Province(No.2109901)
关键词
HMGB1
乳腺组织
临床意义
乳腺癌
浸润性
迁移率
蛋白
导管
infiltrating ductal carcinoma （IDC）
high-mobility group box 1 protein （HMGB1）
clinical staging
lymph node
estrogen receptor （ER）
human epidermal growth factor receptor 2 （HER-2）
