摘要
研究了剂量30 mg·kg-1的氟苯尼考注射液在SD大鼠体内的代谢及生物利用度.静注后药动学特性符合二室开放模型,主要动力学参数:Cmax为36.51±3.25μg·mL-1;AUC(0-t)为51.75±0.21μg·mL-1·h.肌注后药动学特性符合一室开放模型,氟苯尼考及氟苯尼考胺的主要动力学参数:肌注组t1/2β为12.63±0.02 h及21.32±1.02 h;tmax为1.0±0.03 h及8.0±0.02 h;Cmax为6.70±0.12及3.50±0.20μg·mL-1;AUC为45.22±0.21及34.35±1.15μg·mL-1·h.氟苯尼考注射液肌注后在大鼠体内吸收好,分布快,消除缓慢,药动学行为与对照品纽弗罗注射液相似.
The metabolism and bioavailability of florineicol injection (30 mg · kg-1) in SD rats are studied.The results show that the pharmacokinetic behavior after intravenous administration follows a two-compartment open model,with the key parameters Cmax 36.51 ±3.25 μg · mL-1 and AUC (0-t):51.75 ±0.21 μg · mL-1 · h.Pharmacokinetic behavior after intramuscular administration follows a single-compartment open model,the key paramaters of florfenicol and florfenicol amine are as follows:experimental group,t1/2β 12.63 ± 0.02 h and 21.32 ± 1.02h,tmax1.0 ± 0.03hand8.0 ± 0.02h,Cmax6.70 ± 0.12and3.50 ± 0.20μg·mL-1,AUC45.22 ± 0.21 and 34.35 ± 1.15 μg · mL-1 · h,respectively.The results indicates a good absorption,fast distribution and slow elimination of florfenicol after injection in rats.There is no significant pharmacokinetic difference between experimental florfenicol injection and reference Nuflor injection.
出处
《烟台大学学报(自然科学与工程版)》
CAS
2014年第2期122-125,共4页
Journal of Yantai University(Natural Science and Engineering Edition)