低分子肝素与奥扎格雷钠联用治疗急性脑梗死疗效分析

Curative effect of low molecular heparin with the sodium ozagrel combined treatment of acute cerebral infarction

目的探讨低分子肝素与奥扎格雷钠联用治疗急性脑梗死患者的临床疗效。方法将116例急性脑梗死患者随机分为两组,各58例。对照组进行常规治疗,观察组同时给予低分子肝素联合奥扎格雷钠治疗,比较治疗后两组的临床疗效、神经功能缺损评分(NIHSS)、日常生活能力评分(ADL)及不良反应情况。结果观察组治疗总有效率为94.8%,明显高于对照组的70.7%(P<0.01);两组治疗后NIHSS均降低,ADL均增加;观察组NIHSS明显低于对照组,ADL明显高于对照组(P<0.01);两组不良反应发生率差异无统计学意义(P>0.05)。结论低分子肝素与奥扎格雷钠联用治疗急性脑梗死效果较好,可明显提高临床疗效,改善神经功能及日常生活能力。

Objective To study the clinical curative effect of low molecular heparin with the sodium ozagrel combined treat -ment in patients with acute cerebral infarction .Methods One hundred and sixteen cases of acute cerebral infarction were randomly di -vided into two groups .The control group underwent conventional treatment ,and the experimental group was given low molecular heparin combined with sodium ozagrel treatment .The clinical curative effect ,NIHSS and ability of daily life （ ADL） and adverse reactions of the two groups were compared.Results The treatment efficiency of the experimental group （94.8%）was obviously higher than that of control group （ P 〈0.01）.Nerve function defect scores decreased and daily life ability scores increased in both groups after thetreat -ment .NIHSS of the experimental group was significantly lower than that of the control group ,and daily life ability score was significantly higher than that of the control group （ P 〈0.01）.There was no significant difference between the incidence rates of adverse reaction of the two groups（ P ＆gt;0.05）.Conclusion Low molecular heparin combined with sodium ozagrel in treatment of acute cerebral infarc -tion can obviously increase the clinical curative effect ,and improve nerve function and ADL of the patients .