突变型Ras蛋白表达与食管癌复发的相关性分析

Correlation of Mutated Ras Protein Expression with Recurrence in Esophagus Carcinoma

目的分析突变型Ras蛋白表达与食管癌复发的相关性。方法采用免疫组化S-P法检测65例食管癌(复发组43例和未复发组22例)手术标本中突变型Ras蛋白的表达情况。结果复发组Ras蛋白阳性表达率是72.09%(31/43),未复发组是18.18%(4/22)(P<0.05),且其表达与分化程度有关。结论突变型Ras蛋白检测可作为预测食管癌术后是否复发的参考因素。

Objective To investigate the correlation of Ras protein with recurrence in esophagus carcinoma. Methods Immunohistochemistry S-P method was used to detect the mutated Ras protein expression in the 65 pa-tients with undergone surgery for esophagus carcinoma（43 patients with recurrence and 22 patients without recur-rence）. Results The positive rate of mutated Ras protein was 72. 09%（31 / 43）in the patients with recurrence, and was 18. 18%（4 / 22）in the patients without recurrence（P ＆lt; 0. 05）. The expression of mutated Ras protein was related to differentiation. Conclusion Mutated Ras protein may be refered as a factor for predicting the recurrence in esophagus carcinoma.