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Xp11.2易位/TFE3基因融合相关性肾癌的研究进展 被引量：1

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摘要 2004年WHO泌尿及男性生殖系统肿瘤分类将Xpl1．2易位／TFE3基因融合相关性肾癌正式列为独立的肾癌亚型，该肿瘤好发于儿童及青少年，女性多于男性，偶见于中老年人。国外研究旧0报道，其总体发病率虽然很低，但在儿童肾癌患者中约1／3为Xpl1．2易位性肾癌。其主要特点是基因组存在Xpl1．2位点的易位，形成新的融合基因，使转录因子TFE3表达量显著上升。
作者 陶金 张雪培
机构地区 郑州大学第一附属医院泌尿外科
出处 《肿瘤基础与临床》 2014年第2期172-174,共3页 journal of basic and clinical oncology
关键词 肾癌 Xpl1 2 TFE3 融合基因
分类号 R737.11 [医药卫生—肿瘤]
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参考文献16

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二级参考文献12

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肿瘤基础与临床
2014年 第2期

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