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亲环素A在动脉粥样硬化发生过程中的作用 被引量：6

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摘要 亲环素A(cyclophilinA,CyPA)是一种高度保守且广泛存在细胞内、外的多功能蛋白,具有肽基脯氨酰顺/反异构酶活性,参与蛋白质折叠、装配与运输;其在细胞内能与环孢酶素A结合,参与免疫抑制、细胞凋亡,在信号转导中具有重要作用,还可介导胆固醇转运。近年的研究显示CypA还是一种前炎症因子及促粥样硬化分子,介导动脉粥样硬化(atherosclerosis,AS)发生和发展的多个病理过程。本文就CypA在AS的发生过程中的作用作一综述。
作者 许文敏 张新霞
机构地区 深圳市福田医院
出处 《岭南心血管病杂志》 2014年第2期261-263,共3页 South China Journal of Cardiovascular Diseases
关键词 动脉粥样硬化 免疫抑制 前炎性因子
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献21

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二级参考文献23

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共引文献9

同被引文献57

  • 1程勇前,成军.钙离子信号调节亲环素配体研究进展[J].世界华人消化杂志,2007,15(1):56-60. 被引量：4
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引证文献6

二级引证文献29

岭南心血管病杂志
2014年 第2期

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