三甲医院2型糖尿病口服降糖药治疗现状及相关影响因素分析

Analysis and investigate the medication patterns of oral hypoglycemic agents and influence factors in outpatient patients with type 2 diabetes in medical centers

目的调查门诊2型糖尿病患者单纯口服降糖药物治疗现状,并分析影响糖化血红蛋白(HbA1c)达标的可能因素。方法贵阳市三甲医院门诊收集388例符合入选标准的2型糖尿病患者,通过问卷调查收集相关资料,进行统计学分析。结果 (1)388例患者中口服降糖药使用比例依次为双胍类、磺脲类、糖苷酶抑制剂及其它。治疗方案中单药治疗占48.7%,联合用药占51.3%。HbA1c<7.0%的达标率为44.8%。(2)HbA1c达标组与未达标组患者在年龄分布、性别、有无冠心病、糖尿病家族史、口服降糖药物种类等方面无差异(P>0.05),而在BMI、病程长短、低密度脂蛋白胆固醇、甘油三酯、就诊前1个月内发生低血糖事件次数及每天活动量等方面有明显差异(P<0.05)。结论 (1)贵阳地区三甲医院门诊2型糖尿病患者血糖控制达标率(HbA1c<7.0%)目前处于国内调查的平均水平。(2)为求糖化血红蛋白达标应该注意BMI、病程长短、低密度脂蛋白胆固醇、甘油三酯、就诊前1个月内发生低血糖事件次数及每天活动量等相关影响因素的控制。

Objective To investigate the medication patterns of simple oral hypoglycemic agents in outpatient patients with type 2 diabetes and analyze the possible factors affecting glycemic control . Methods 388 patients with type 2 diabetic who met the inclusion criteria from three class hospital of Guiyang were enrolled into the study .Patients＆#39;relevant information was collected by face to face ques-tionnaire survey .Results The ordinal ratio of oral anti-diabetic drugs consumption among the patients was metformin ,sulfonylureas ,α-glucosidase inhibitors and others .For therapeutic protocols ,48 .7%of patients were undertaking the oral medication alone ,while 51 .3% of patients with combination ther-apy .There were 44 .8% of patients targeted HbA1c＆lt;7% .The patients in the well-controlled and in the inadequately-controlled diabetic groups were similar in terms of age distribution ,gender ,family history of coronary heart disease ,family history of diabetes and types of oral hypoglycemic agents （P＆gt;0 .05） ,but there were statistically significant differences among the following aspects such as BMI , duration of disease ,low-density lipoprotein ,triglycerides ,number of hypoglycemic events in a month before treatment and daily activity （P＆lt;0 .05） .Conclusion The overall glycemic control in Guiyang is in the average level of the national survey .In order to reach the overall glycemic control ,BMI ,duration of disease ,low-density lipoprotein ,triglycerides ,number of hypoglycemic events in a month before treatment and daily activity should be controlled strictly .