LEEP刀联合保妇康栓治疗高危型HPV感染CIN的临床观察

Efficacy of LEEP knife combined with Baofukang suppository in the treatment of CIN and high risk- HPV infection

目的:探讨高危型HPV感染CIN患者的治疗方法,为高危型HPV感染CIN患者的早期治疗寻求新途径。方法:对2006年3月至2010年6月在我院诊断的高危型HPV感染的CIN患者140例进行随机分组后治疗,分为LEEP联合保妇康栓组、LEEP组,治疗后随访2年,复查监测指标,观察每组的治疗效果。结果:LEEP组治疗后6个月、12个月、18个月及2 4个月的高危型HPV清除率分别为80.0%、82.9%、84.3%、92.9%,LEEP联合保妇康栓组的分别为82.9%、94.3%、95.7%、98.6%,2组相比有显著性差异。治疗后2年的宫颈活检结果显示LEEP联合保妇康栓组的CIN率低于LEEP组。结论:LEEP联合保妇康栓治疗可提高高危型HPV感染CIN患者的HPV清除率,降低CIN复发率,优于其他单一治疗方法。

Objective：To investigate the clinical efficacy of LFLEP combined with Baofukang suppository, in the treatment of cervical intraepithelial neoplasia（CIN） patients with high risk human papillomavirus（hr- HPV） infec- tion. Methods：From 2006 March to 2010 June,140 women diagnosed as CIN combined with hr - HPV infection were randomly divided into 2 groups：LEEP ＋ Baofukang suppository group（n=70） and LEEP group （n=70）. To observe the monitoring indicators and curative effect in two years after treatment. Results： LEEP group, hr - HPV clearance rates were 80% ,82.9% ,84.3%, 92.9% after treatment for 6 months, 12 months, 18 months and 24 months; in LEEP combined with Baofukang suppository group were 82.9% ,94.3% ,95.7% ,98.6%. The results showed the in- cidence of CIN in LEEP combined with Baofukang suppository, groups were lower than the LEEP group. Conclusion： LEEP combined with Baofukang suppository in the treatment of CIN and hr - HPV infection can improve the HPV re- moval rate and reduce the recurrence rate of CIN,which is better than LEEP group.