消化性溃疡临床治疗中四联疗法的效果观察

Observation of effects of quadruple therapy in treatment of peptic ulcer

目的:就四联疗法对于消化性溃疡的治疗效果进行分析和讨论。方法:以192例消化性溃疡并幽门螺杆菌(HP)阳性患者作为分析对象,采取四联疗法对患者进行为期14d的治疗,并对治疗结果和不良反应情况进行统计。结果:在112例胃溃疡患者中,有96例患者治愈,12例患者好转,4例患者无效,临床治愈率为85.7%。在80例十二指肠溃疡患者中,有72例患者治愈,8例患者好转,0例患者无效,临床治愈率为90%。在不良反应方面,有4例患者出现轻微的呕吐和恶心症状,均在短时间内自行消除,未出现严重的用药不良反应。结论:本次研究所采用的四联疗法对于消化性溃疡具有疗效显著,不良反应轻微的满意效果,值得在今后的临床实践中进行推广和应用。

Objective：To analyze and discuss effects of quadruple therapy in treatment of peptic ulcer. Methods：192 cases ofpeptic ulcer combined with positive HP in our hospital from January 2012 to January 2013 were selected and treated with the quadrupletherapy for 14 days. Then, the effects and adverse reactions were statistically analyzed. Results： In the 112 cases with gastric ulcer, 96patients were cured, 12 cases were improved, 4 patients had no changes, and the clinical cure rate was 85. 7%. In 80 cases with duo-denal ulcer, 72 patients were cured, 8 patients were improved, 0 case had no changes, and the clinical cure rate was 90%. In the ad-verse reactions, there were four cases with mild symptoms of vomiting and nausea, which were eliminated in a short time by them-selves, and there were no serious adverse drug reactions. Conclusions： The quadruple therapy was used in the institute in the treatmentof peptic ulcer has a significant effect and mild adverse reactions. Therefore, it is worth being used in the clinical fields in future.