治疗女性生殖道解脲支原体感染的临床研究

Clinical analysis on treatment of ureaplasma urealyticum infection in female genital tract

目的：探讨阿奇霉素联合阴道抑菌凝胶治疗女性生殖道解脲支原体感染的临床疗效及不良反应．方法：选取我院于2011-05／2013-05收治的生殖道解脲支原体感染女性患者共50例，将其随机分为两组，分别为试验组和对照组，每组25例，其中对照组给予阿奇霉素治疗，每天给予阿奇霉素片剂（0．25mg/片），每次1片，2次／d，连服3周．试验组在给予阿奇霉素片剂治疗的基础上（用法和用量与对照组相同），还给予阴道抑菌凝胶治疗，患者睡前清洗外阴，然后将阴道抑菌凝胶推入阴道深处，每次1支，1次／d，连用3周．比较两组之间临床症状的改善情况及出现不良反应的情况．结果：对照组25例患者的总有效率为68．0％；试验组25例患者的总有效率为92．0％，与对照组相比，差异具有统计学意义（P〈0．05）．试验组有1例患者服药后出现恶心、腹泻等胃肠道不良反应，有2例患者在阴道上药后出现外阴皮肤瘙痒、阴道伴有灼热感，停药后逐渐消失；对照组有3例患者服药后出现恶心、腹泻等胃肠道不良反应，停药后逐渐好转．因此，试验组和对照组所出现的不良反应之间并无统计学差异（P〉0．05）．结论：阿奇霉素联合阴道抑菌凝胶治疗女性生殖道解脲支原体感染的临床疗效比单独使用阿奇霉素治疗要好，且不良反应与单独使用阿奇霉素治疗相当，建议在临床上推广使用．

AIM： To investigate the clinical efficacy and adverse reactions of azithromycin and vaginal gel in the treatment of female genital tract antibacterial ureaplasma urealyticum infection. METHODS： 50 patients with ureaplasma urealyticum infection admitted to our hospital from May 2011 to May 2013 were divided into two groups randomly, the test group and the control group （25 cases in each group）. The control group received treatment of Azithromycin, Azithromycin tablet administered （0. 25 rag/ piece）, twice a day for three weeks. We give the test group anti- bacterial gel in the treatment of vaginal along with Azithromycin tablets therapy （ the same usage and dosage as the control group）. Patients cleaned the vulva before bedtime, and then one pushed vagina antibacterial gel into the vagina, once a day for three weeks. Improvement and adverse reactions of the clinical symp- toms of the situation between the two groups were compared. RE- SULTS ： The total effective rate of 25 patients in the control group was 68.0%; The total effective rate of 25 patients in the test group was 92.0%, and the difference was statistically significant （P 〈 0.05 ） compared with the control group. There are one pa- tient occurring gastrointestinal adverse reactions such as nausea medication and diarrhea, and two patients appearing vaginal geni- tal itching accompanied by vaginal burning sensation in the test group. But these symptoms gradually disappear after treatment. There are three patients occurring gastrointestinal adverse reac- tions such as nausea medication and diarrhea, but symptoms grad- ually disappear after treatment. Accordingly, there is no signifi- cant difference between the adverse reactions in the control group and the test group （P 〉 0.05 ）. CONCLUSION： Clinical effects of Azithromycin and vaginal gel in the treatment of female genital tract antibacterial ureaplasma urealyticum infection are better than the treatment of Azithromycin solely, and the adverse reactions are equal to treatment of Azithromycin solely. Therefore, we recom- mend the clinical use of Azithromycin combined with vaginal anti-bacteria gel.